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Table 3 Hematological analysis after administration of Myelophil for 13 weeks

From: Acute and repeated toxicological study of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, in beagle dogs

MYP (mg/kg) Male Female
0 312.5 625 1250 0 312.5 625 1250
Number 5 3 3 5 5 3 3 5
WBC (103/μL) 9.4 ± 0.8 10.6 ± 2.2 10.0 ± 2.1 8.4 ± 1.3 7.6 ± 0.7 8.1 ± 1.6 8.7 ± 1.6 9.0 ± 1.7
WBC Differential Counts (%)
 NE 52.0 ± 3.5 54.3 ± 4.6 49.3 ± 8.7 62.1 ± 3.0 50.3 ± 8.1 55.5 ± 5.2 50.5 ± 4.0 50.1 ± 10.2
 LY 36.8 ± 6.2 37.0 ± 4.2 41.5 ± 11.4 38.8 ± 2.4 39.2 ± 7.7 35.3 ± 6.7 41.9 ± 3.9 42.1 ± 10.5
 MO 4.9 ± 1.2 4.0 ± 0.7 4.4 ± 1.9 4.5 ± 1.3 4.5 ± 0.8 5.0 ± 1.4 4.5 ± 0.9 4.0 ± 1.0
 EO 5.8 ± 3.3 4.2 ± 1.1 4.3 ± 1.2 4.1 ± 0.9 5.3 ± 2.9 3.6 ± 1.2 2.3 ± 0.7 3.2 ± 1.3
 BA 0.3 ± 0.2 0.4 ± 0.1 0.3 ± 0.2 0.4 ± 0.1 0.6 ± 0.2 0.4 ± 0.3 0.6 ± 0.2 0.5 ± 0.2
RBC (106/μL) 7.3 ± 0.6 7.8 ± 0.3 7.5 ± 0.6 8.0 ± 0.3 8.3 ± 0.6 8.2 ± 0.8 8.4 ± 0.7 8.3 ± 0.7
Hemoglobin (g/dL) 16.3 ± 0.9 16.4 ± 0.6 16.0 ± 1.1 17.1 ± 0.9 18.5 ± 1.1 17.6 ± 1.2 18.9 ± 1.6 18.3 ± 1.2
Hematocrit (%) 49.6 ± 2.6 50.7 ± 1.4 49.7 ± 3.1 52.8 ± 2.4 57.4 ± 3.7 55.4 ± 3.8 57.6 ± 4.5 56.4 ± 3.9
MCV (fL) 68.2 ± 2.5 64.8 ± 2.1 66.7 ± 2.2 66.1 ± 3.2 69.0 ± 1.4 67.7 ± 1.8 68.4 ± 1.1 68.4 ± 1.7
MCH (pg) 22.5 ± 0.7 20.9 ± 0.8 21.4 ± 1.1 21.4 ± 1.3 22.3 ± 0.5 21.5 ± 0.7 22.4 ± 0.0 22.2 ± 0.7
MCHC (g/dL) 32.9 ± 0.2 32.3 ± 0.3 32.1 ± 0.5 32.4 ± 0.5 32.3 ± 0.4 31.7 ± 0.5 32.8 ± 0.5 32.4 ± 0.3
RDW (%) 14.1 ± 0.6 14.4 ± 0.2 14.7 ± 1.5 14.6 ± 0.9 13.4 ± 0.9 13.6 ± 0.4 13.8 ± 0.6 14.2 ± 1.1
Platelet (103/μL) 327.0 ± 44.2 326.3 ± 68.3 380.7 ± 35.6 349.6 ± 73.9 301.8 ± 54.0 352.7 ± 87.8 329.0 ± 62.4 326.4 ± 52.9
MPV (fL) 16.3 ± 1.4 17.8 ± 1.1 17.0 ± 0.3 16.6 ± 1.3 16.5 ± 1.1 16.4 ± 2.4 17.2 ± 0.8 16.6 ± 0.7
Reticulocytes (%) 1.1 ± 0.3 1.1 ± 0.2 1.1 ± 0.6 1.0 ± 0.3 0.8 ± 0.2 1.0 ± 0.3 1.1 ± 0.3 0.9 ± 0.2
PT (sec) 6.0 ± 0.2 6.00 ± 0.1 6.0 ± 0.2 6.0 ± 0.2 6.0 ± 0.2 6.1 ± 0.1 6.3 ± 0.3 6.1 ± 0.2
aPTT (sec) 12.3 ± 0.7 12.1 ± 0.3 12.2 ± 1.0 12.2 ± 0.8 12.8 ± 1.3 12.9 ± 0.8 11.5 ± 1.5 12.5 ± 0.6
  1. After administration of MYP for 13 weeks, hematology was analyzed to compare the MYP-treated groups to the control group
  2. WBC White blood cell, NE Neutrophil, LY Lymphocyte, MO Monocyte, EO Eosinophil, BA Basophil, RBC Red blood cell, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration, RDW Red cell distribution width, MPV Mean platelet volume, PT Prothrombin time, APPT Activated partial thromboplastin time