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Table 2 Summary of the repeated toxicity test in beagle dogs

From: Acute and repeated toxicological study of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, in beagle dogs

MYP (mg/kg per day) 0 312.5 625 1250
Number (M/F) 10 (5/5) 6(3/3) 6(3/3) 10 (5/5)
Mortality
Anorexia −+ −+ −+ −+
Soft stool + + ++ +++
Compound-colored stool ++ +++
Food intake NAD NAD NAD NAD
Ophthalmological findings NAD NAD NAD NAD
Relative organ weight NS NS NS NS
Necropsy findings NAD NAD NAD NAD
  1. Beagle dogs in each group were fed MYP, and the clinical symptoms, including mortality, were monitored for 13 weeks. At the end of the experiment, ophthalmological, necropsy-based examinations were performed
  2. NAD No abnormality detected, NS Not significant; −: Absent; +: Slight; ++: Moderate; +++: Severe; −+: Sporadically detected