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Table 1 Summary of the acute toxicity test in beagle dogs

From: Acute and repeated toxicological study of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, in beagle dogs

MYP (mg/kg) 0 1250 2500 5000
Number (M/F) 2 (1/1) 2(1/1) 2(1/1) 2 (1/1)
Mortality
Vomiting on the day of
administration
++ (M, F)
Vomiting on the day after of
administration
+ (F) + (F)
Compound-colored stool + (M)
Body weight change
Necropsy findings NAD NAD NAD NAD
  1. Beagle dogs in each group were fed Myelophil (MYP). Clinical signs were observed for 6 h after drug administration; thereafter, daily mortality and symptoms were observed for 2 weeks. At the end of the experiment, necropsy was performed
  2. M Male, F Female, NAD No abnormality detected; −: Absent; +: Slight; ++: Moderate