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Table 2 Animal characteristics and glycemic control in SHAM and ANG II-treated rats and in ANG II-treated rats following chronic administration of RA at 10, 20, or 40 mg/kg

From: Rosmarinic acid improves hypertension and skeletal muscle glucose transport in angiotensin II-treated rats

  SHAM ANG II   RA-10c RA-20c RA-40c
Body weight (g)
 Initial weight 374.10 ± 6.08 372.92 ± 7.30   383.71 ± 5.87   373.28 ± 5.89   379.00 ± 4.71  
 Final weight (BW) 400.80 ± 4.79 369.16 ± 9.57 * 363.99 ± 11.71 * 383.77 ± 11.85   373.24 ± 9.82  
Liver weight (LW; g) 11.64 ± 0.36 10.02 ± 0.27 * 10.44 ± 0.45   10.99 ± 0.43   10.68 ± 0.38  
LW/kg BW (g/kg) 28.80 ± 0.75 28.53 ± 0.64   28.63 ± 0.60   28.64 ± 0.69   28.58 ± 0.55  
Heart weight (HW; g) 1.21 ± 0.04 1.34 ± 0.04   1.32 ± 0.04   1.30 ± 0.04   1.31 ± 0.03  
HW/kg BW (g/kg) 2.98 ± 0.10 3.75 ± 0.14 * 3.65 ± 0.14 * 3.42 ± 0.13   3.52 ± 0.11 *
Fasting plasma glucose (mmol/l) 6.83 ± 0.06 8.12 ± 0.36 * 7.18 ± 0.15 7.10 ± 0.18 7.08 ± 0.16
Fasting plasma insulin (mU/l) 37.83 ± 2.96 33.09 ± 6.19   32.16 ± 3.21   38.27 ± 5.41   36.52 ± 7.06  
HOMA-IR 12.24 ± 1.35 14.27 ± 3.44   10.50 ± 0.98   12.87 ± 2.14   12.53 ± 2.64  
Glucose AUC (mg/ml/min*104) 1.80 ± 0.03 2.04 ± 0.14   2.05 ± 0.12   1.82 ± 0.05   2.10 ± 0.17  
Insulin AUC (μU/ml/min*103) 7.08 ± 0.71 5.46 ± 0.61 * 5.52 ± 0.70 * 5.17 ± 0.53 * 5.26 ± 0.66 *
G-I index (μU/ml/min*mg/ml/min*107) 13.10 ± 1.55 11.75 ± 2.19   10.48 ± 1.59   9.55 ± 0.99   10.38 ± 1.34  
  1. * P < 0.05 vs. SHAM group; P < 0.05 vs. ANG II group. HOMA-IR: homeostasis model assessment-estimated insulin resistance; G-I index: glucose-insulin index