SHAM | ANG II | RA-10c | RA-20c | RA-40c | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Body weight (g) | |||||||||||||||||||
Initial weight | 374.10 | ± | 6.08 | 372.92 | ± | 7.30 | 383.71 | ± | 5.87 | 373.28 | ± | 5.89 | 379.00 | ± | 4.71 | ||||
Final weight (BW) | 400.80 | ± | 4.79 | 369.16 | ± | 9.57 | * | 363.99 | ± | 11.71 | * | 383.77 | ± | 11.85 | 373.24 | ± | 9.82 | ||
Liver weight (LW; g) | 11.64 | ± | 0.36 | 10.02 | ± | 0.27 | * | 10.44 | ± | 0.45 | 10.99 | ± | 0.43 | 10.68 | ± | 0.38 | |||
LW/kg BW (g/kg) | 28.80 | ± | 0.75 | 28.53 | ± | 0.64 | 28.63 | ± | 0.60 | 28.64 | ± | 0.69 | 28.58 | ± | 0.55 | ||||
Heart weight (HW; g) | 1.21 | ± | 0.04 | 1.34 | ± | 0.04 | 1.32 | ± | 0.04 | 1.30 | ± | 0.04 | 1.31 | ± | 0.03 | ||||
HW/kg BW (g/kg) | 2.98 | ± | 0.10 | 3.75 | ± | 0.14 | * | 3.65 | ± | 0.14 | * | 3.42 | ± | 0.13 | 3.52 | ± | 0.11 | * | |
Fasting plasma glucose (mmol/l) | 6.83 | ± | 0.06 | 8.12 | ± | 0.36 | * | 7.18 | ± | 0.15 | † | 7.10 | ± | 0.18 | † | 7.08 | ± | 0.16 | † |
Fasting plasma insulin (mU/l) | 37.83 | ± | 2.96 | 33.09 | ± | 6.19 | 32.16 | ± | 3.21 | 38.27 | ± | 5.41 | 36.52 | ± | 7.06 | ||||
HOMA-IR | 12.24 | ± | 1.35 | 14.27 | ± | 3.44 | 10.50 | ± | 0.98 | 12.87 | ± | 2.14 | 12.53 | ± | 2.64 | ||||
Glucose AUC (mg/ml/min*104) | 1.80 | ± | 0.03 | 2.04 | ± | 0.14 | 2.05 | ± | 0.12 | 1.82 | ± | 0.05 | 2.10 | ± | 0.17 | ||||
Insulin AUC (μU/ml/min*103) | 7.08 | ± | 0.71 | 5.46 | ± | 0.61 | * | 5.52 | ± | 0.70 | * | 5.17 | ± | 0.53 | * | 5.26 | ± | 0.66 | * |
G-I index (μU/ml/min*mg/ml/min*107) | 13.10 | ± | 1.55 | 11.75 | ± | 2.19 | 10.48 | ± | 1.59 | 9.55 | ± | 0.99 | 10.38 | ± | 1.34 |