Rosmarinic acid improves hypertension and skeletal muscle glucose transport in angiotensin II-treated rats

Table 2 Animal characteristics and glycemic control in SHAM and ANG II-treated rats and in ANG II-treated rats following chronic administration of RA at 10, 20, or 40 mg/kg

	SHAM			ANG II				RA-10c				RA-20c				RA-40c
Body weight (g)
Initial weight	374.10	±	6.08	372.92	±	7.30		383.71	±	5.87		373.28	±	5.89		379.00	±	4.71
Final weight (BW)	400.80	±	4.79	369.16	±	9.57	*	363.99	±	11.71	*	383.77	±	11.85		373.24	±	9.82
Liver weight (LW; g)	11.64	±	0.36	10.02	±	0.27	*	10.44	±	0.45		10.99	±	0.43		10.68	±	0.38
LW/kg BW (g/kg)	28.80	±	0.75	28.53	±	0.64		28.63	±	0.60		28.64	±	0.69		28.58	±	0.55
Heart weight (HW; g)	1.21	±	0.04	1.34	±	0.04		1.32	±	0.04		1.30	±	0.04		1.31	±	0.03
HW/kg BW (g/kg)	2.98	±	0.10	3.75	±	0.14	*	3.65	±	0.14	*	3.42	±	0.13		3.52	±	0.11	*
Fasting plasma glucose (mmol/l)	6.83	±	0.06	8.12	±	0.36	*	7.18	±	0.15	†	7.10	±	0.18	†	7.08	±	0.16	†
Fasting plasma insulin (mU/l)	37.83	±	2.96	33.09	±	6.19		32.16	±	3.21		38.27	±	5.41		36.52	±	7.06
HOMA-IR	12.24	±	1.35	14.27	±	3.44		10.50	±	0.98		12.87	±	2.14		12.53	±	2.64
Glucose AUC (mg/ml/min*10⁴)	1.80	±	0.03	2.04	±	0.14		2.05	±	0.12		1.82	±	0.05		2.10	±	0.17
Insulin AUC (μU/ml/min*10³)	7.08	±	0.71	5.46	±	0.61	*	5.52	±	0.70	*	5.17	±	0.53	*	5.26	±	0.66	*
G-I index (μU/ml/minmg/ml/min10⁷)	13.10	±	1.55	11.75	±	2.19		10.48	±	1.59		9.55	±	0.99		10.38	±	1.34

* P < 0.05 vs. SHAM group; ^† P < 0.05 vs. ANG II group. HOMA-IR: homeostasis model assessment-estimated insulin resistance; G-I index: glucose-insulin index

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