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Table 1 Animal characteristics and glycemic control in SHAM and ANG II-treated rats and in ANG II-treated rats following acute administration of RA at 10, 20, or 40 mg/kg

From: Rosmarinic acid improves hypertension and skeletal muscle glucose transport in angiotensin II-treated rats

  SHAM ANG II   RA-10a RA-20a RA-40a
Body weight (g)
 Initial weight 373.55 ± 5.58 372.25 ± 5.83   364.41 ± 9.07   365.47 ± 7.23   368.03 ± 5.48  
 Final weight (BW) 408.53 ± 6.34 366.40 ± 13.23 * 358.02 ± 9.77 * 362.86 ± 9.28 * 358.94 ± 9.18 *
Liver weight (LW; g) 10.80 ± 0.31 9.30 ± 0.20 * 9.25 ± 0.25 * 9.66 ± 0.50 * 9.93 ± 0.50 *
LW/kg BW (g/kg) 26.96 ± 0.85 27.04 ± 0.86   26.67 ± 0.58   27.86 ± 0.82   28.01 ± 0.85  
Heart weight (HW; g) 1.12 ± 0.04 1.26 ± 0.02   1.27 ± 0.04   1.29 ± 0.04   1.31 ± 0.03  
HW/kg BW (g/kg) 2.81 ± 0.07 3.67 ± 0.17 * 3.66 ± 0.11 * 3.75 ± 0.13 * 3.71 ± 0.12 *
Fasting plasma glucose (mmol/l) 6.81 ± 0.07 8.35 ± 0.45 8.29 ± 0.25 8.33 ± 0.38 7.18 ± 0.32  
Fasting plasma insulin (mU/l) 39.74 ± 2.67 35.46 ± 6.61   28.03 ± 3.83   34.37 ± 4.51   33.23 ± 4.80  
HOMA-IR 11.96 ± 1.18 13.10 ± 3.14   10.62 ± 1.49   12.99 ± 2.24   10.40 ± 1.83  
Glucose AUC (mg/ml/min*104) 1.85 ± 0.04 2.19 ± 0.15   2.32 ± 0.22   2.46 ± 0.18   2.34 ± 0.13  
Insulin AUC (μU/ml/min*103) 7.32 ± 0.66 5.31 ± 0.47 * 4.48 ± 0.68 * 5.08 ± 0.67 * 4.78 ± 0.51 *
G-I index (μU/ml/min*mg/ml/min*107) 13.90 ± 1.40 12.33 ± 1.70   9.77 ± 1.98   11.71 ± 1.67   10.66 ± 1.22  
  1. *P < 0.05 vs. SHAM group; § P < 0.05 vs. RA-40a group. HOMA-IR: homeostasis model assessment-estimated insulin resistance; G-I index: glucose-insulin index