Unit | Control | Asdamarin (mg/kg) | ||||
---|---|---|---|---|---|---|
250 | 500 | 1000 | 1000 Reversal | |||
Male | ||||||
ALT | IU/L | 209.2 ± 69.38 | 212.0 ± 60.64 | 146.8 ± 7.14 | 219.0 ± 46.85 | 66.0 ± 6.88 |
AST | IU/L | 296.9 ± 53.02 | 279.6 ± 43.44 | 228.6 ± 10.88 | 238.8 ± 25.25 | 208.4 ± 20.78 |
ALP | IU/L | 276.9 ± 39.06 | 246.1 ± 5.54 | 221.4 ± 29.71 | 207.2 ± 18.54 | 299.3 ± 39.60 |
Total Protein | g/dL | 6.20 ± 0.39 | 12.08 ± 3.37 | 8.0 ± 1.36 | 5.90 ± 1.33 | 8.52 ± 0.46 |
Albumin | mg/dL | 3.60 ± 0.19 | 4.58 ± 0.76 | 5.24 ± 1.37 | 6.62 ± 1.59 | 4.06 ± 0.25 |
Glucose | mg/dL | 115.7 ± 6.16 | 135.1 ± 7.95 | 92.22 ± 16.19 | 131.3 ± 19.92 | 114.9 ± 10.15 |
Total bilirubin | mg/dL | 0.24 ± 0.24 | 0.24 ± 0.02 | 0.26 ± 0.04 | 0.74 ± 0.31 | 0.26 ± 0.024 |
Direct bilirubin | mg/dL | 0.12 ± 0.02 | 0.10 ± 0.03 | 0.160 ± 0.04 | 0.14 ± 0.05 | 0.120 ± 0.02 |
Urea | mg/dL | 37.43 ± 5.72 | 35.17 ± 3.32 | 33.83 ± 3.83 | 48.17 ± 4.30 | 54.67 ± 6.33 |
Creatinine | mg/dL | 0.64 ± 0.07 | 0.79 ± 0.31 | 2.18 ± 1.14 | 1.74 ± 0.91 | 0.84 ± 0.05 |
Cholesterol | mg/dL | 53.03 ± 7.22 | 57.13 ± 5.34 | 63.78 ± 2.80 | 58.57 ± 21.28 | 78.85 ± 6.40 |
Triglycerides | mg/dL | 52.57 ± 14.57 | 51.34 ± 10.32 | 66.43 ± 9.29 | 58.75 ± 20.85 | 70.86 ± 6.37 |
HDL | mg/dL | 43.08 ± 4.87 | 47.99 ± 3.80 | 50.11 ± 1.60 | 53.53 ± 6.99 | 68.72 ± 5.94** |
Calcium | mg/dL | 9.87 ± 0.78 | 19.37 ± 9.54 | 12.60 ± 3.15 | 14.56 ± 4.40 | 10.96 ± 0.55 |
Phosphorous | mg/dL | 17.32 ± 6.07 | 24.04 ± 6.85 | 22.38 ± 3.1 | 26.08 ± 11.58 | 21.34 ± 16.60 |
Female | ||||||
ALT | IU/L | 74.40 ± 4.88 | 105.0 ± 15.44 | 101.4 ± 10.46 | 108.6 ± 16.59 | 52.2 ± 7.14 |
AST | IU/L | 170.6 ± 7.69 | 180.4 ± 15.46 | 178.5 ± 17.91 | 189.0 ± 23.67 | 175.5 ± 9.74 |
ALP | IU/L | 160.0 ± 17.89 | 190.5 ± 31.15 | 142.7 ± 6.46 | 184.6 ± 34.12 | 165.4 ± 18.7 |
Total Protein | g/dL | 13.90 ± 1.24 | 14.1 ± 1.56 | 11.48 ± 1.00 | 11.84 ± 1.59 | 10.58 ± 1.14 |
Albumin | mg/dL | 4.08 ± 0.08 | 3.86 ± 0.09 | 3.720 ± 0.31 | 3.82 ± 0.198 | 3.66 ± 0.19 |
Glucose | mg/dL | 107.7 ± 9.17 | 117.8 ± 22.54 | 121.1 ± 11.32 | 110.1 ± 34.12 | 109.9 ± 6.27 |
Total bilirubin | mg/dL | 0.28 ± 0.04 | 0.34 ± 0.14 | 0.36 ± 0.09 | 0.26 ± 0.07 | 0.32 ± 0.037 |
Direct bilirubin | mg/dL | 0.16 ± 0.02 | 0.18 ± 0.08 | 0.24 ± 0.05 | 0.14 ± 0.02 | 0.16 ± 0.02 |
Urea | mg/dL | 123.2 ± 13.82 | 107.8 ± 17.75 | 150.7 ± 36.99 | 130.7 ± 12.54 | 51.49 ± 3.86 |
Creatinine | mg/dL | 0.43 ± 0.04 | 1.09 ± 0.66 | 1.83 ± 1.21 | 1.04 ± 0.17 | 0.69 ± 0.1 |
Cholesterol | mg/dL | 69.58 ± 8.39 | 55.86 ± 4.96 | 53.24 ± 6.20 | 63.03 ± 8.54 | 61.76 ± 3.76 |
Triglycerides | mg/dL | 65.15 ± 12.15 | 44.65 ± 13.84 | 53.12 ± 10.79 | 44.05 ± 23.35 | 101.7 ± 29.26 |
HDL | mg/dL | 64.70 ± 5.65 | 60.44 ± 5.52 | 62.44 ± 6.70 | 68.13 ± 3.76 | 74.76 ± 3.92 |
Calcium | mg/dL | 9.41 ± 0.19 | 8.44 ± 0.42 | 9.54 ± 0.90 | 7.35 ± 2.65 | 9.33 ± 0.13 |
Phosphorous | mg/dL | 23.02 ± 2.88 | 14.90 ± 5.17 | 13.28 ± 5.31 | 22.70 ± 6.80 | 24.42 ± 4.2 |