Table 2 Effect of Asdamarin on average water consumption (mL) in rats
Sex | Day | Control | 250 mg/kg | 500 mg/kg | 1000 mg/kg | 1000 mg/kg reversal |
|---|---|---|---|---|---|---|
Male | 7 | 28.46 ± 0.94 | 27.49 ± 0.99 | 35.71 ± 1.08 | 30.8 ± 1.15 | 36.63 ± 1.81 |
14 | 34.46 ± 1.35 | 32.46 ± 3.27 | 39.54 ± 2.68 | 36.51 ± 0.96 | 38.57 ± 2.43 | |
21 | 35.46 ± 2.50 | 30.57 ± 1.10 | 44.74 ± 0.65 | 41.69 ± 1.53 | 39.06 ± 1.14 | |
28 | 30.69 ± 1.46 | 32.74 ± 1.49 | 30.14 ± 0.55 | 42.8 ± 1.72 | 38.66 ± 1.79 | |
35 | – | – | – | – | 37.09 ± 2.27 | |
42 | – | – | – | – | 36.94 ± 1.05 | |
Female | 7 | 30.51 ± 1.14 | 25.77 ± 1.19 | 26.46 ± 2.84 | 29.29 ± 1.31 | 27.63 ± 3.13 |
14 | 29.6 ± 29.69 | 24.4 ± 28.03 | 28.8 ± 30.11 | 33.2 ± 35.54 | 28.00 ± 29.09 | |
21 | 32.00 ± 29.89 | 27.00 ± 24.17 | 27.6 ± 25.60 | 35.00 ± 34.17 | 36.2 ± 30.14 | |
28 | 32.83 ± 2.83 | 36.8 ± 2.43 | 35.94 ± 1.91 | 38.26 ± 2.20 | 37.11 ± 2.06 | |
35 | – | – | – | – | 40.31 ± 3.37 | |
42 | – | – | – | – | 27.17 ± 2.13 |