Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying

Table 1 Effect of Asdamarin on mean feed consumption (g) in rats

Sex	Day	Control	250 mg/kg	500 mg/kg	1000 mg/kg	1000 mg/kg reversal
Male	7	17.83 ± 0.95	16.8 ± 0.42	18.31 ± 0.7	18.19 ± 0.61	21.7 ± 0.86
	14	18.8 ± 0.36	17.72 ± 0.93	22.13 ± 0.7	20.12 ± 0.58	24.36 ± 0.47
	21	20.84 ± 0.46	19.3 ± 0.24	24.64 ± 0.57	21.44 ± 0.72	23.92 ± 0.14
	28	21.54 ± 1.03	20.09 ± 0.47	24.03 ± 0.54	22.81 ± 0.69	23.3 ± 0.66
	35	–	–	–	–	19.78 ± 0.29
	42	–	–	–	–	23.95 ± 0.35
Female	7	14.62 ± 0.30	14.18 ± 0.46	13.86 ± 0.35	12.61 ± 0.90	14.00 ± 0.82
	14	15.83 ± 0.57	16.43 ± 0.48	15.15 ± 0.33	17.17 ± 0.34	16.90 ± 1.27
	21	15.77 ± 0.87	15.81 ± 0.33	15.11 ± 0.54	17.12 ± 0.30	17.63 ± 0.28
	28	16.35 ± 0.68	17.74 ± 0.68	17.22 ± 0.39	18.89 ± 0.52	19.63 ± 1.11
	35	–	–	–	–	20.69 ± 0.49
	42	–	–	–	–	18.88 ± 1.08

Values are expressed as mean ± s.e.m. (n = 10 for each group). Data were analyzed by one-way Anova. *p < 0.05 were considered as statistically significant compared to control

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