Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

Table 5 Effect of cisplatin (CP) and different treatments of AHE on cardiac tissue protein, oxidative stress markers and lipid peroxidation

Group	Protein (μg/mg Tissue)	H₂O₂ (nM/min/mg Tissue)	Nitrite content (NO μM/ml)	MDA (nM/min/mg protein)
Control	1.638 ± 0.033	1.932 ± 0.015	42.59 ± 0.552	2.874 ± 0.180
CP	1.061 ± 0.075^***	5.975 ± 0.025^***	75.72 ± 0.707^***	7.711 ± 0.264^***
AHE alone	1.614 ± 0.015⁺⁺⁺	1.911 ± 0.049⁺⁺⁺	41.72 ± 0.650⁺⁺⁺	2.859 ± 0.086⁺⁺⁺
CP + AHE	1.419 ± 0.028^*,+++	5.016 ± 0.013^***,+++	62.63 ± 0.765^***,+++	5.774 ± 0.285^***,+++,###
AHE + CP	1.536 ± 0.032⁺⁺⁺	2.794 ± 0.005^**,+++	49.93 ± 0.419^**,+++	3.219 ± 0.189⁺⁺⁺
CP + Sily	1.564 ± 0.019⁺⁺⁺	2.717 ± 0.006^**,+++	50.60 ± 0.322^**,+++	3.225 ± 0.112⁺⁺⁺

Data are represented mean ± S.E.M (n = 6). Asterisks ^{*, **, ***} indicates p < 0.05, 0.001, 0.0001 vs. control; ^{+, ++, +++} indicates p < 0.05, 0.001, 0.0001 vs. CP alone; ^{#, ##, ###} indicates p < 0.05, 0.001, 0.0001 vs. AHE + CP. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)

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