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Table 4 Effect of cisplatin (CP) and different treatments of AHE on cardiac enzymatic antioxidant levels and GSH profile

From: Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

Group

GSH (μM/g tissue)

GR (nM/min/mg protein)

GST (nM/min/mg protein)

γ-GT (nM/min/mg Protein)

GPx (nM/min/mg Protein)

Control

20.55 ± 0.280

154.9 ± 0.958

148.6 ± 0.665

303.5 ± 0.811

122.4 ± 0.639

CP

12.41 ± 0.278***

111.8 ± 1.569***

110.9 ± 1.002***

100.6 ± 0.947***

66.77 ± 0.924***

AHE alone

20.66 ± 0.236+++

155.6 ± 0.439+++

148.4 ± 0.816+++

306.9 ± 0.401+++

122.9 ± 0.285+++

CP + AHE

14.34 ± 0.23***,++,###

121.6 ± 1.086***,+++,###

123.9 ± 1.110***,+++,###

189.3 ± 0.559***,+++,###

81.51 ± 1.659***,+++,###

AHE + CP

18.43 ± 0.415**,###

147.3 ± 0.948**,+++

141.7 ± 0.60**,+++

293.9 ± 0.602**,+++

111.7 ± 0.602***,+++

CP + Sily

18.33 ± 0.293**,###

146.0 ± 1.055**,+++

141.0 ± 0.899**,+++

294.7 ± 0.999**,+++

115.1 ± 1.00**,+++

  1. Data are represented mean ± S.E.M (n = 6). Asterisks *, **, *** indicates p < 0.05, 0.001, 0.0001 vs. control; +, ++, +++ indicates p < 0.05, 0.001, 0.0001 vs. CP alone; #, ##, ### indicates p < 0.05, 0.001, 0.0001 vs. AHE + CP. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)