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Table 5 Serum lipid profile in rats treated orally with GLES for 90 days

From: Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

  Control GLES1 GLES2 GLES3
Female Male Female Male Female Male Female Male
CHOL (mg/dL) 72.97 ± 5.41 63.71 ± 3.47 69.88 ± 3.47 55.21 ± 3.09 84.17 ± 6.18 44.02 ± 1.54*** 91.51 ± 4.63* 44.40 ± 2.70***
TG (mg/dL) 30.12 ± 3.47 19.69 ± 1.93 38.61 ± 6.18 14.67 ± 1.16* 28.57 ± 3.09 11.97 ± 1.16*** 28.96 ± 3.09 9.65 ± 0.77***
HDL-C (mg/dL) 52.90 ± 3.47 20.85 ± 4.25 49.42 ± 2.32 22.39 ± 3.86 61.78 ± 4.63 14.29 ± 3.47 67.95 ± 3.47* 19.31 ± 4.25
LDL-C (mg/dL) 6.95 ± 2.32 33.98 ± 3.47 4.25 ± 1.54 26.25 ± 2.70 9.65 ± 2.70 24.32 ± 3.09 10.42 ± 1.54 20.46 ± 2.70**
VLDLC (mg/dL) 6.02 ± 0.69 3.94 ± 0.35 7.68 ± 1.27 2.90 ± 0.23* 5.75 ± 0.66 2.39 ± 0.19*** 5.79 ± 0.58 1.89 ± 0.12***
CRR 1.37 ± 0.018 4.45 ± 0.80 1.41 ± 0.02 3.45 ± 0.67 1.37 ± 0.02 4.88 ± 0.88 1.35 ± 0.02 3.53 ± 0.69
CRI-2 0.12 ± 0.03 2.81 ± 0.69 0.09 ± 0.03 2.04 ± 0.59 0.14 ± 0.04 3.30 ± 0.77 0.15 ± 0.02 2.18 ± 0.62
AC 0.37 ± 0.02 3.44 ± 0.80 0.41 ± 0.02 2.45 ± 0.67 0.37 ± 0.02 3.88 ± 0.88 0.35 ± 0.02 2.53 ± 0.69
AIP −0.263 ± 0.061 0.058 ± 0.089 −0.147 ± 0.051 −0.115 ± 0.083 −0.346 ± 0.073 0.019 ± 0.010 −0.382 ± 0.051 −0.210 ± 0.097
  1. n = 10 rats/sex/group; data are presented as mean ± SEM
  2. *indicates significant difference (p < 0.05) compared to the control
  3. **indicates significant difference (p < 0.01) compared to the control
  4. ***indicates significant difference (p < 0.001) compared to the control