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Table 5 Serum lipid profile in rats treated orally with GLES for 90 days

From: Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

 

Control

GLES1

GLES2

GLES3

Female

Male

Female

Male

Female

Male

Female

Male

CHOL (mg/dL)

72.97 ± 5.41

63.71 ± 3.47

69.88 ± 3.47

55.21 ± 3.09

84.17 ± 6.18

44.02 ± 1.54***

91.51 ± 4.63*

44.40 ± 2.70***

TG (mg/dL)

30.12 ± 3.47

19.69 ± 1.93

38.61 ± 6.18

14.67 ± 1.16*

28.57 ± 3.09

11.97 ± 1.16***

28.96 ± 3.09

9.65 ± 0.77***

HDL-C (mg/dL)

52.90 ± 3.47

20.85 ± 4.25

49.42 ± 2.32

22.39 ± 3.86

61.78 ± 4.63

14.29 ± 3.47

67.95 ± 3.47*

19.31 ± 4.25

LDL-C (mg/dL)

6.95 ± 2.32

33.98 ± 3.47

4.25 ± 1.54

26.25 ± 2.70

9.65 ± 2.70

24.32 ± 3.09

10.42 ± 1.54

20.46 ± 2.70**

VLDLC (mg/dL)

6.02 ± 0.69

3.94 ± 0.35

7.68 ± 1.27

2.90 ± 0.23*

5.75 ± 0.66

2.39 ± 0.19***

5.79 ± 0.58

1.89 ± 0.12***

CRR

1.37 ± 0.018

4.45 ± 0.80

1.41 ± 0.02

3.45 ± 0.67

1.37 ± 0.02

4.88 ± 0.88

1.35 ± 0.02

3.53 ± 0.69

CRI-2

0.12 ± 0.03

2.81 ± 0.69

0.09 ± 0.03

2.04 ± 0.59

0.14 ± 0.04

3.30 ± 0.77

0.15 ± 0.02

2.18 ± 0.62

AC

0.37 ± 0.02

3.44 ± 0.80

0.41 ± 0.02

2.45 ± 0.67

0.37 ± 0.02

3.88 ± 0.88

0.35 ± 0.02

2.53 ± 0.69

AIP

−0.263 ± 0.061

0.058 ± 0.089

−0.147 ± 0.051

−0.115 ± 0.083

−0.346 ± 0.073

0.019 ± 0.010

−0.382 ± 0.051

−0.210 ± 0.097

  1. n = 10 rats/sex/group; data are presented as mean ± SEM
  2. *indicates significant difference (p < 0.05) compared to the control
  3. **indicates significant difference (p < 0.01) compared to the control
  4. ***indicates significant difference (p < 0.001) compared to the control