Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

Table 3 Hematology values in rats treated orally with GLES for 90 days

	Control		GLES1		GLES2		GLES3
	Female	Male	Female	Male	Female	Male	Female	Male
WBC (*10⁹/L)	6.08 ± 0.81	9.47 ± 1.62	6.96 ± 0.85	8.87 ± 1.26	5.37 ± 0.73	8.87 ± 1.09	8.09 ± 1.15	7.47 ± 0.86
RBC (*10¹²/L)	7.20 ± 0.24	8.92 ± 0.13	7.64 ± 0.12	8.92 ± 0.25	7.29 ± 0.15	8.67 ± 0.13	7.99 ± 0.15**	8.45 ± 0.23
HGB (g/L)	137.30 ± 1.64	152.20 ± 1.56	142.50 ± 1.97	151.90 ± 2.70	134.20 ± 3.33	146.60 ± 2.03	144.10 ± 2.61	147.70 ± 1.92
PLT (*10⁹/L)	865.70 ± 36.62	875.80 ± 48.90	824.10 ± 37.34	901.60 ± 43.82	918.50 ± 79.82	953.50 ± 61.47	968.5 ± 43.83	931.20 ± 71.60
PCV (*10¹²/L)	0.42 ± 0.01	0.45 ± 0.01	0.45 ± 0.01	0.46 ± 0.02	0.43 ± 0.01	0.43 ± 0.01	0.44 ± 0.01	0.43 ± 0.01
MCV (fL)	58.60 ± 1.00	50.60 ± 1.18	58.40 ± 0.96	51.20 ± 1.81	58.60 ± 1.23	49.70 ± 1.09	55.50 ± 0.64	51.40 ± 1.30
MCH (pg)	19.40 ± 0.86	17.20 ± 0.20	18.50 ± 0.22	17.20 ± 0.29	18.30 ± 0.26	16.90 ± 0.23	18.10 ± 0.23	17.50 ± 0.34
MCHC (g/L)	329.50 ± 11.63	338.90 ± 5.98	319.70 ± 1.71	336.10 ± 8.46	315.00 ± 3.96	341.40 ± 5.31	325.30 ± 2.19	342.10 ± 5.39
LYM# (*10³/μL)	4.09 ± 0.63	6.12 ± 0.93	3.62 ± 0.85	6.41 ± 0.92	3.68 ± 0.53	5.70 ± 0.81	5.45 ± 0.75	4.93 ± 0.59
NEU# (*10³/μL)	1.47 ± 0.20	2.64 ± 0.66	1.78 ± 0.26	1.92 ± 0.37	1.23 ± 0.20	2.35 ± 0.41	1.80 ± 0.31	2.08 ± 0.27
RDW (%)	14.32 ± 0.31	18.01 ± 0.23	14.35 ± 0.56	18.42 ± 0.38	15.02 ± 0.66	17.90 ± 0.36	14.37 ± 0.22	16.82 ± 0.59

ISSN: 2662-7671