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Table 3 Hematology values in rats treated orally with GLES for 90 days

From: Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

  Control GLES1 GLES2 GLES3
Female Male Female Male Female Male Female Male
WBC (*109/L) 6.08 ± 0.81 9.47 ± 1.62 6.96 ± 0.85 8.87 ± 1.26 5.37 ± 0.73 8.87 ± 1.09 8.09 ± 1.15 7.47 ± 0.86
RBC (*1012/L) 7.20 ± 0.24 8.92 ± 0.13 7.64 ± 0.12 8.92 ± 0.25 7.29 ± 0.15 8.67 ± 0.13 7.99 ± 0.15** 8.45 ± 0.23
HGB (g/L) 137.30 ± 1.64 152.20 ± 1.56 142.50 ± 1.97 151.90 ± 2.70 134.20 ± 3.33 146.60 ± 2.03 144.10 ± 2.61 147.70 ± 1.92
PLT (*109/L) 865.70 ± 36.62 875.80 ± 48.90 824.10 ± 37.34 901.60 ± 43.82 918.50 ± 79.82 953.50 ± 61.47 968.5 ± 43.83 931.20 ± 71.60
PCV (*1012/L) 0.42 ± 0.01 0.45 ± 0.01 0.45 ± 0.01 0.46 ± 0.02 0.43 ± 0.01 0.43 ± 0.01 0.44 ± 0.01 0.43 ± 0.01
MCV (fL) 58.60 ± 1.00 50.60 ± 1.18 58.40 ± 0.96 51.20 ± 1.81 58.60 ± 1.23 49.70 ± 1.09 55.50 ± 0.64 51.40 ± 1.30
MCH (pg) 19.40 ± 0.86 17.20 ± 0.20 18.50 ± 0.22 17.20 ± 0.29 18.30 ± 0.26 16.90 ± 0.23 18.10 ± 0.23 17.50 ± 0.34
MCHC (g/L) 329.50 ± 11.63 338.90 ± 5.98 319.70 ± 1.71 336.10 ± 8.46 315.00 ± 3.96 341.40 ± 5.31 325.30 ± 2.19 342.10 ± 5.39
LYM# (*103/μL) 4.09 ± 0.63 6.12 ± 0.93 3.62 ± 0.85 6.41 ± 0.92 3.68 ± 0.53 5.70 ± 0.81 5.45 ± 0.75 4.93 ± 0.59
NEU# (*103/μL) 1.47 ± 0.20 2.64 ± 0.66 1.78 ± 0.26 1.92 ± 0.37 1.23 ± 0.20 2.35 ± 0.41 1.80 ± 0.31 2.08 ± 0.27
RDW (%) 14.32 ± 0.31 18.01 ± 0.23 14.35 ± 0.56 18.42 ± 0.38 15.02 ± 0.66 17.90 ± 0.36 14.37 ± 0.22 16.82 ± 0.59
  1. n = 10 rats/sex/group; data are presented as mean ± SEM
  2. **indicates significant difference (p < 0.01) between GLES3 and the control