Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

Table 2 Relative organ weights of rats treated orally with GLES for 90 days

	Control		GLES1		GLES2		GLES3
	Female	Male	Female	Male	Female	Male	Female	Male
Relative weight (g/100 g Body weight)
Liver	2.91 ± 0.07	2.42 ± 0.07	3.34 ± 0.08*	2.81 ± 0.15	3.49 ± 0.15**	3.14 ± 0.15***	3.72 ± 0.13***	3.09 ± 0.12**
Kidneys	0.57 ± 0.01	0.59 ± 0.02	0.57 ± 0.02	0.60 ± 0.02	0.57 ± 0.01	0.64 ± 0.02	0.56 ± 0.012	0.57 ± 0.01
Spleen	0.19 ± 0.01	0.19 ± 0.01	0.18 ± 0.01	0.17 ± 0.01	0.19 ± 0.01	0.19 ± 0.01	0.19 ± 0.01	0.16 ± 0.01
Adipose tissue	0.77 ± 0.07	0.72 ± 0.07	0.85 ± 0.12	0.46 ± 0.06**	0.63 ± 0.07	0.42 ± 0.05**	0.57 ± 0.04	0.38 ± 0.03***
Heart	0.33 ± 0.01	0.30 ± 0.006	0.33 ± 0.01	0.30 ± 0.007	0.33 ± 0.01	0.30 ± 0.004	0.30 ± 0.01	0.28 ± 0.007
Lungs	0.78 ± 0.06	0.56 ± 0.03	0.83 ± 0.13	0.56 ± 0.02	0.69 ± 0.02	0.53 ± 0.02	0.69 ± 0.04	0.55 ± 0.04
Cerebrum	0.60 ± 0.01	0.40 ± 0.02	0.51 ± 0.02*	0.39 ± 0.01	0.56 ± 0.03	0.38 ± 0.02	0.45 ± 0.02***	0.40 ± 0.01
Thymus	0.10 ± 0.01	0.08 ± 0.01	0.12 ± 0.01	0.07 ± 0.01	0.09 ± 0.01	0.07 ± 0.01	0.11 ± 0.01	0.07 ± 0.01
Adrenal glands	0.019 ± 0.001	0.016 ± 0.002	0.021 ± 0.002	0.015 ± 0.002	0.021 ± 0.001	0.015 ± 0.001	0.023 ± 0.001*	0.015 ± 0.001
Ovaries (or testis)	0.037 ± 0.002	0.94 ± 0.01	0.041 ± 0.001	0.89 ± 0.03	0.037 ± 0.002	0.87 ± 0.04	0.041 ± 0.001	0.83 ± 0.04*
Uterus	0.29 ± 0.02	N/A	0.24 ± 0.02	N/A	0.24 ± 0.01	N/A	0.26 ± 0.02	N/A

ISSN: 2662-7671