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Table 2 Relative organ weights of rats treated orally with GLES for 90 days

From: Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

  Control GLES1 GLES2 GLES3
Female Male Female Male Female Male Female Male
Relative weight (g/100 g Body weight)
 Liver 2.91 ± 0.07 2.42 ± 0.07 3.34 ± 0.08* 2.81 ± 0.15 3.49 ± 0.15** 3.14 ± 0.15*** 3.72 ± 0.13*** 3.09 ± 0.12**
 Kidneys 0.57 ± 0.01 0.59 ± 0.02 0.57 ± 0.02 0.60 ± 0.02 0.57 ± 0.01 0.64 ± 0.02 0.56 ± 0.012 0.57 ± 0.01
 Spleen 0.19 ± 0.01 0.19 ± 0.01 0.18 ± 0.01 0.17 ± 0.01 0.19 ± 0.01 0.19 ± 0.01 0.19 ± 0.01 0.16 ± 0.01
 Adipose tissue 0.77 ± 0.07 0.72 ± 0.07 0.85 ± 0.12 0.46 ± 0.06** 0.63 ± 0.07 0.42 ± 0.05** 0.57 ± 0.04 0.38 ± 0.03***
 Heart 0.33 ± 0.01 0.30 ± 0.006 0.33 ± 0.01 0.30 ± 0.007 0.33 ± 0.01 0.30 ± 0.004 0.30 ± 0.01 0.28 ± 0.007
 Lungs 0.78 ± 0.06 0.56 ± 0.03 0.83 ± 0.13 0.56 ± 0.02 0.69 ± 0.02 0.53 ± 0.02 0.69 ± 0.04 0.55 ± 0.04
 Cerebrum 0.60 ± 0.01 0.40 ± 0.02 0.51 ± 0.02* 0.39 ± 0.01 0.56 ± 0.03 0.38 ± 0.02 0.45 ± 0.02*** 0.40 ± 0.01
 Thymus 0.10 ± 0.01 0.08 ± 0.01 0.12 ± 0.01 0.07 ± 0.01 0.09 ± 0.01 0.07 ± 0.01 0.11 ± 0.01 0.07 ± 0.01
 Adrenal glands 0.019 ± 0.001 0.016 ± 0.002 0.021 ± 0.002 0.015 ± 0.002 0.021 ± 0.001 0.015 ± 0.001 0.023 ± 0.001* 0.015 ± 0.001
 Ovaries (or testis) 0.037 ± 0.002 0.94 ± 0.01 0.041 ± 0.001 0.89 ± 0.03 0.037 ± 0.002 0.87 ± 0.04 0.041 ± 0.001 0.83 ± 0.04*
 Uterus 0.29 ± 0.02 N/A 0.24 ± 0.02 N/A 0.24 ± 0.01 N/A 0.26 ± 0.02 N/A
  1. n = 10 rats/sex/group; data are presented as mean ± SEM
  2. *indicates significant difference (p < 0.05) compared to the control
  3. **indicates significant difference (p < 0.01) compared to the control
  4. ***indicates significant difference (p < 0.001) compared to the control