Table 6 Pharmacokinetic parameters of cucurbitacin B

C_max (μg/L)

N/A

9.70 ± 3.95

31.24 ± 10.50

T_max (h)

N/A

0.50 ± 0.00

0.60 ± 0.22

AUC_0-t (μg·h/L)

13.92 ± 11.11

15.10 ± 3.57

45.22 ± 10.14

AUC_0-inf (μg·h/L)

17.95 ± 13.21

25.33 ± 12.13

52.42 ± 29.58

Normalized AUC_0-inf (μg·h/L)

N/A

12.67 ± 6.07

13.11 ± 7.40

F (%)

N/A

10.25 ± 7.29

10.25 ± 5.63

V_d (L/kg)

51.65 ± 39.16

N/A

N/A

CL (L/h/kg)

7.24 ± 2.92

N/A

N/A

t_1/2 (h)

5.08 ± 2.87

N/A

N/A

MRT (h)

6.03 ± 2.93

9.95 ± 12.27

5.50 ± 2.28