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Table 6 Pharmacokinetic parameters of cucurbitacin B

From: Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats

Parameters Cucurbitacin B 0.1 mg/kg IV Cucurbitacin B 2 mg/kg PO Cucurbitacin B 4 mg/kg PO
Cmax (μg/L) N/A 9.70 ± 3.95 31.24 ± 10.50
Tmax (h) N/A 0.50 ± 0.00 0.60 ± 0.22
AUC0-t (μg·h/L) 13.92 ± 11.11 15.10 ± 3.57 45.22 ± 10.14
AUC0-inf (μg·h/L) 17.95 ± 13.21 25.33 ± 12.13 52.42 ± 29.58
Normalized AUC0-inf (μg·h/L) N/A 12.67 ± 6.07 13.11 ± 7.40
F (%) N/A 10.25 ± 7.29 10.25 ± 5.63
Vd (L/kg) 51.65 ± 39.16 N/A N/A
CL (L/h/kg) 7.24 ± 2.92 N/A N/A
t1/2 (h) 5.08 ± 2.87 N/A N/A
MRT (h) 6.03 ± 2.93 9.95 ± 12.27 5.50 ± 2.28
  1. The values represent as mean ± SD (n = 6). Cmax, maximum plasma concentration; Tmax, time to maximum plasma concentration; AUC0-t, area under the curve from time zero to last sampling time point; AUC0-inf Area under the curve from time zero to infinity, F Absolute oral bioavailability, Vd Volume of distribution, CL Clearance, t1/2 Elimination half-life, MRT Mean residence time