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Table 5 General appearance and biochemical markers indicating liver and kidney functions before and after cucurbitacin B treatment

From: Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats

Parameters Cucurbitacin B 0.1 mg/kg IV Cucurbitacin B 2 mg/kg PO Cucurbitacin B 4 mg/kg PO
Pre-dosing (0 h) Post-dosing (24 h) Pre-dosing (0 h) Post-dosing (24 h) Pre-dosing (0 h) Post-dosing (24 h)
General appearance Normal Normal Normal Normal Normal Normal
AST (U/L) 35.40 ± 4.15 49.20 ± 3.27 36.67 ± 1.53 32.33 ± 11.68 33.50 ± 8.10 50.25 ± 0.96
ALT (U/L) 11.40 ± 6.31 11.00 ± 3.94 11.00 ± 1.00 6.33 ± 1.53 16.75 ± 6.50 12.25 ± 5.62
Creatinine (mg/dL) 0.22 ± 0.03 0.23 ± 0.02 0.20 ± 0.02 0.19 ± 0.03 0.23 ± 0.02 0.22 ± 0.03
  1. The data represent as mean ± SD (n = 6). AST, aspartate aminotransferase; ALT, alanine aminotransferase