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Table 6 Packed cell volume, rectal temperature and body weight of infected mice treated with 80% methanol extract of the leaves of Olea europaea in prophylactic test

From: Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Groups

Packed cell volume

Rectal temperature

Body weight

D 0

D3

% change

D0

D3

% change

D0

D3

% change

2% TW80

58.56 ± 0.38

56.47 ± 0.38

−3.57

36.10 ± 0.14

35.20 ± 0.14

−2.49

28.35 ± 0.40

27.65 ± 0.39

−2.45

CQ25 mg/kg

58.70 ± 0.65

58.59 ± 0.67

−0.19a3

35.81 ± 0.22

35.74 ± 0.20

0.22a3

28.77 ± 0.38

28.87 ± 0.38

0.36a3

200 mg/kg

58.65 ± 0.49

57.3 ± 0.48

−2.30a3b3d1e2

36.06 ± 0.12

35.30 ± 0.11

−2.08b3d2e2

28.76 ± 0.38

28.09 ± 0.38

−2.32b3

400 mg/kg

59.10 ± 0.49

57.91 ± 0.47

−2.01a3b3

36.40 ± 0.14

35.86 ± 0.13

−1.50a3b3

29.04 ± 0.34

28.40 ± 0.35

−2.20a1b3

600 mg/kg

58.70 ± 0.66

57.56 ± 0.67

−1.91a3b3

36.07 ± 0.13

35.71 ± 0.13

−1.00a3b3

28.86 ± 0.55

28.24 ± 0.53

−2.13a2b3

  1. Data are expressed as mean ± SEM; n = 6; a, compared to negative control; b, to CQ25 mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine, D0 pre-inoculation value on day 0, D3 post- treatment value on day 3 after inoculation