Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Table 6 Packed cell volume, rectal temperature and body weight of infected mice treated with 80% methanol extract of the leaves of Olea europaea in prophylactic test

Groups	Packed cell volume			Rectal temperature			Body weight
Groups	D 0	D3	% change	D0	D3	% change	D0	D3	% change
2% TW80	58.56 ± 0.38	56.47 ± 0.38	−3.57	36.10 ± 0.14	35.20 ± 0.14	−2.49	28.35 ± 0.40	27.65 ± 0.39	−2.45
CQ25 mg/kg	58.70 ± 0.65	58.59 ± 0.67	−0.19^a3	35.81 ± 0.22	35.74 ± 0.20	0.22^a3	28.77 ± 0.38	28.87 ± 0.38	0.36^a3
200 mg/kg	58.65 ± 0.49	57.3 ± 0.48	−2.30^a3b3d1e2	36.06 ± 0.12	35.30 ± 0.11	−2.08^b3d2e2	28.76 ± 0.38	28.09 ± 0.38	−2.32^b3
400 mg/kg	59.10 ± 0.49	57.91 ± 0.47	−2.01^a3b3	36.40 ± 0.14	35.86 ± 0.13	−1.50^a3b3	29.04 ± 0.34	28.40 ± 0.35	−2.20^a1b3
600 mg/kg	58.70 ± 0.66	57.56 ± 0.67	−1.91^a3b3	36.07 ± 0.13	35.71 ± 0.13	−1.00^a3b3	28.86 ± 0.55	28.24 ± 0.53	−2.13^a2b3

Data are expressed as mean ± SEM; n = 6; a, compared to negative control; b, to CQ25 mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine, D0 pre-inoculation value on day 0, D3 post- treatment value on day 3 after inoculation

ISSN: 2662-7671