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Table 4 Packed cell volume, rectal temperature and body weight of infected mice treated with 80% methanol extract of the leaves of Olea europaea in Rane’s test

From: Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Groups

Packed cell volume

Rectal temperature

Body weight

D3

D7

% change

D3

D7

% change

D3

D7

% change

2% TW80

51.86 ± 0.53

43.20 ± 0.36

−16.69

35.36 ± 0.17

33.51 ± 0.13

−5.25

28.43 ± 0.72

25.70 ± 0.74

−9.65

CQ25 mg/kg

50.31 ± 0.42

51.84 ± 0.35

3.05a3

35.18 ± 0.11

35.47 ± 0.13

0.83a3

28.63 ± 0.61

29.07 ± 0.63

1.51a3

200 mg/kg

51.93 ± 0.59

46.62 ± 0.63

−10.23a3b3d2e3

35.31 ± 0.25

33.71 ± 0.24

−4.52a1b3d1e3

27.00 ± 0.60

24.71 ± 0.64

−8.50b3

400 mg/kg

51.84 ± 0.68

47.86 ± 0.70

−7.68a3b3

35.36 ± 0.09

34.05 ± 0.13

−3.72a3b3

28.22 ± 0.49

26.04 ± 0.46

−7.71a2b3

600 mg/kg

51.78 ± 0.43

48.26 ± 0.53

−6.81a3b3

35.36 ± 0.07

34.23 ± 0.06

−3.18a3b3

27.63 ± 0.49

25.59 ± 0.50

−3.39a2b3

  1. Data are expressed as mean ± SEM; n = 6; a, compared to negative control; b, to CQ25 mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine, D3 pre-treatment value on day 3, D4 post- treatment value on day 7