Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Table 2 Packed cell volume, rectal temperature and body weight of infected mice treated with 80% methanol extract of the leaves of Olea europaea in the 4-day suppressive test

Groups	Packed cell volume			Rectal temperature			Body weight
Groups	D0	D4	% change	D0	D4	% change	D0	D4	% change
2% TW80	61.81 ± 1.16	56.19 ± 1.09	−9.09	36.74 ± 0.06	34.8 ± 0.18	−5.28	28.25 ± 0.41	26.93 ± 0.41	−4.66
CQ25 mg/kg	61.52 ± 1.13	61.20 ± 1.12	−0.52^a3	35.52 ± 0.27	35.51 ± 0.20	−0.03^a3	28.93 ± 0.34	29.26 ± 0.37	1.13^a3
200 mg/kg	59.61 ± 0.68	56.60 ± 0.77	−5.05^a3b3d3e3	36.23 ± 0.20	34.96 ± 0.17	−3.50^a2b3e2	28.95 ± 0.32	27.79 ± 0.35	−4.00^b3
400 mg/kg	62.08 ± 0.77	60.15 ± 0.73	−3.10^a3b3	36.46 ± 0.17	35.67 ± 0.22	−2.16^a3b2	29.03 ± 0.49	28.05 ± 0.47	−3.39^a2b3
600 mg/kg	62.05 ± 0.65	60.51 ± 0.67	−2.49^a3b3	36.00 ± 0.18	35.56 ± 0.16	−1.22^a3	28.02 ± 0.74	27.16 ± 0.79	−3.06^a2b3

Data are expressed as mean ± SEM; n = 6; a, compared to negative control; b, to CQ25 mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine, D0 pre-treatment value on day 0, D4 post- treatment value on day 4

ISSN: 2662-7671