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Table 3 Biological activity of RHTR in cell lines and BALB/c mice

From: Biological and toxicological evaluation of Rhus trilobata Nutt. (Anacardiaceae) used traditionally in mexico against cancer

  AE FF Vincristine IX PBS
Cells In vitro studies: IC50, SI and LD50
IC50 CACO-2 5 (High) 18 (High) 25 (High) >  800 (Very low)
IC50 BEAS-2B 800 (Very low) 600 (Very low) 25 (High) >  800 (Very low)
IC50 CHO-K1 600 (Very low) 600 (Very low) 57 (medium) >  800 (Very low)
SI 140 +++ 33.3 ++ 1.64 + ND
LD50 [Theoretical] 1141.5 1209 350 ND
  In vivo studies: acute toxicity
Sign toxicity None None ND None
Survivors (%) 100 100 ND 100
Final weight (g) 28.6 ± 2.4 28.2 ± 2.4 ND 26.5 ± 2.3
  1. The results show the mean ± S.D. of three biological replicates (n = 3, in triplicate)
  2. The values in parentheses correspond to the biological activity of the samples
  3. Selective index (SI) indicate specific activity on cancer cells vs normal cells (+++, very high; ++, high; +, low)
  4. ND not determined, IC50 half-maximal inhibitory concentration (μg/mL), LD50 median lethal dose (oral, mg/kg), AE aqueous extract, FF flavonoid fraction