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Table 3 Biological activity of RHTR in cell lines and BALB/c mice

From: Biological and toxicological evaluation of Rhus trilobata Nutt. (Anacardiaceae) used traditionally in mexico against cancer

 

AE

FF

Vincristine

IX PBS

Cells

In vitro studies: IC50, SI and LD50

IC50 CACO-2

5 (High)

18 (High)

25 (High)

>  800 (Very low)

IC50 BEAS-2B

800 (Very low)

600 (Very low)

25 (High)

>  800 (Very low)

IC50 CHO-K1

600 (Very low)

600 (Very low)

57 (medium)

>  800 (Very low)

SI

140 +++

33.3 ++

1.64 +

ND

LD50 [Theoretical]

1141.5

1209

350

ND

 

In vivo studies: acute toxicity

Sign toxicity

None

None

ND

None

Survivors (%)

100

100

ND

100

Final weight (g)

28.6 ± 2.4

28.2 ± 2.4

ND

26.5 ± 2.3

  1. The results show the mean ± S.D. of three biological replicates (n = 3, in triplicate)
  2. The values in parentheses correspond to the biological activity of the samples
  3. Selective index (SI) indicate specific activity on cancer cells vs normal cells (+++, very high; ++, high; +, low)
  4. ND not determined, IC50 half-maximal inhibitory concentration (μg/mL), LD50 median lethal dose (oral, mg/kg), AE aqueous extract, FF flavonoid fraction