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Table 2 Effect of catechin and morphine in formalin-induced nociception test

From: Antinociceptive activities of Artocarpus lacucha Buch-ham (Moraceae) and its isolated phenolic compound, catechin, in mice

Treatment Dose (mg/Kg) Nociceptive response (s) Edema thickness (mm) % inhibition
Early Phase (0–10 min) % inhibition Late Phase (11–45 min) % inhibition
Vehicle 118.18 ± 2.80 487.37 ± 17.41 1.37 ± 0.03
Morphine 5 21.45 ± 2.29* 81.35 22.65 ± 1.37* 95.35 0.72 ± 0.04* 47.67
(+)-Catechin 50 114.05 ± 2.62 3.49 404.17 ± 13.08 17.07 1.34 ± 0.01 2.62
(+)-Catechin 100 112.43 ± 2.28 4.86 377.18 ± 7.11* 22.61 1.11 ± 0.02* 19.24
(+)-Catechin 200 110.56 ± 2.38 6.45 338.19 ± 3.48* 30.61 0.92 ± 0.01* 33.24
  1. Data are presented as mean ± SEM (n = 5). * represents p < 0.001, compared to control group mice