Antinociceptive activities of Artocarpus lacucha Buch-ham (Moraceae) and its isolated phenolic compound, catechin, in mice

Table 1 Effect of hydro-alcoholic extract of A. lacucha (HEBA) in formalin-induced nociception test

Treatment	Dose (mg/Kg)	Nociceptive response (s)				Edema thickness (mm)	% inhibition
Treatment	Dose (mg/Kg)	Early Phase (0–10 min)	% inhibition	Late Phase (11–45 min)	% inhibition	Edema thickness (mm)	% inhibition
Vehicle	–	113.56 ± 1.82	–	407.21 ± 5.46	–	1.45 ± 0.07	–
Morphine	5	22.59 ± 2.27^*	80.11	28.33 ± 2.43^*	93.04	0.78 ± 0.06^**	45.93
HEBA	50	66.73 ± 9.43^*	41.24	167.34 ± 9.61^*	58.91	1.10 ± 0.03^*	24.00
HEBA	100	50.87 ± 1.96^*	55.21	122.45 ± 8.78^*	69.93	0.94 ± 0.06^*	35.31
HEBA	200	34.59 ± 0.65^*	69.54	106.80 ± 4.05^*	73.77	0.85 ± 0.07^*	41.10

Data are presented as mean ± SEM (n = 5). HEBA = hydro-methanolic extract of A. lacucha bark. ^* and ^** represents p < 0.001 and p < 0.01 compared to control group mice

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