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Table 5 Histomorphometrical analysis of the colon and remnant fecal pellets in the constipation rats induced by LP

From: Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats

Groups Histomorphometry (at sacrifice)
Fecal pellet surface mucous thicknesses (μm) Mucous producing cell numbers (cells/mm2) Colon mucosa thicknesses (μm)
Control
 Intact 62.28 ± 17.39 610.38 ± 140.52 523.25 ± 118.89
 LP 14.42 ± 2.05a 148.50 ± 46.34a 214.56 ± 38.30a
Reference
 SP 5 mg/kg 101.83 ± 17.48ac 482.25 ± 57.62c 405.61 ± 51.15bc
FBe treated as
 300 mg/kg 76.09 ± 13.22c 380.25 ± 70.14ac 362.15 ± 56.27ac
 200 mg/kg 54.12 ± 12.84c 308.13 ± 45.17ac 314.98 ± 86.75ac
 100 mg/kg 26.68 ± 9.42ac 274.88 ± 60.44ac 273.14 ± 22.32ac
  1. Values are expressed mean ± S.D. of eight rat samples
  2. FBe = Triple fermented barley extracts, test material
  3. SP = Sodium picosulfate
  4. LP = Loperamide
  5. a p < 0.01 and b p < 0.05 as compared with intact control by MW test
  6. c p < 0.01 as compared with LP control by MW test