Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats

Table 3 Fecal parameters in the constipation rats induced by LP

Time/Index Groups	Collected at 1 day before treatment for 24 h				Collected from after 4th administration for 24 h
Time/Index Groups	Pellet numbers = (numbers/rat)	Wet-weights (g/rat)	Dry-weights (g/rat)	Water contents (%/rat)	Pellet numbers (numbers/rat)	Wet-weights (g/rat)	Dry-weights (g/rat)	Water contents (%/rat)
Control
Intact	60.25 ± 12.43	9.72 ± 1.46	6.67 ± 1.57	32.06 ± 3.76	57.75 ± 11.67	9.71 ± 1.29	6.63 ± 1.23	32.16 ± 3.69
LP	61.25 ± 12.52	9.65 ± 0.91	9.74 ± 0.92	30.33 ± 3.24	32.50 ± 6.21^a	3.81 ± 0.75^a	3.34 ± 0.58^a	11.91 ± 4.04^a
Reference
SP 5 mg/kg	62.50 ± 13.21	10.37 ± 1.44	7.39 ± 1.55	29.38 ± 5.97	67.88 ± 11.34^c	10.66 ± 1.35^c	7.14 ± 1.10^c	33.08 ± 5.68^c
FBe treated as
300 mg/kg	62.25 ± 11.18	9.61 ± 1.45	6.48 ± 1.48	33.10 ± 5.62	59.00 ± 11.64^c	9.73 ± 1.37^c	7.11 ± 1.05^c	26.99 ± 2.71^bc
200 mg/kg	60.75 ± 16.59	9.96 ± 1.73	6.87 ± 1.84	31.90 ± 6.26	54.38 ± 10.93^c	9.28 ± 1.30^c	7.08 ± 0.94^c	23.51 ± 5.18^ac
100 mg/kg	60.88 ± 13.65	10.10 ± 1.32	7.01 ± 1.66	31.43 ± 7.86	44.00 ± 7.69^bd	8.21 ± 0.79^bc	6.73 ± 0.57^c	18.01 ± 2.77^ac

Values are expressed mean ± S.D. of eight rats
FBe = Triple fermented barley extracts, test material
SP = Sodium picosulfate
LP = Loperamide
To determine fecal dry weights, all collected fecal pellets were dried at 60 °C in a general dry oven for 24 h
Fecal pellet water contents (%) = [(fecal wet-weight – fecal dry-weigh)/fecal wet-weight] × 100
^ap < 0.01 and ^b p < 0.05 as compared with intact control by LSD test
^cp < 0.01 and ^d p < 0.05 as compared with LP control by LSD test

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