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Table 1 Therapeutic effect of SSEE against CCl4-induced hepatotoxicity related parameters in rats

From: Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

Liver function parameters GI (Control) GII (CCl4-only) GIII (CCl4+ SSEE 100 mg) GIV (CCl4+ SSEE 200 mg) GV (CCl4+ Silymarin 10 mg)
AST (U/L) 107.45 ± 5.31 294.83 ± 8.33*** 288.50 ± 7.36 b 262.50 ± 6.87b 136.66 ± 6.00**b
ALT (U/L) 28.83 ± 2.20 230.83 ± 9.62***a 198.16 ± 7.12*b 159.50 ± 9.17***b 85.66 ± 4.31***b
ALP (U/L) 321.66 ± 13.8 515.16 ± 13.7***a 479.00 ± 6.12* b 436.33 ± 12.31**b 396.33 ± 7.62***b
GGT (U/L) 4.06 ± 0.32 12.85 ± 0.98***a 11.38 ± 0.49b 9.46 ± 0.32**b 5.58 ± 0.28***b
BIL (mg/dL) 0.54 ± 0.01 2.16 ± 0.08***a 1.81 ± 0.05*b 1.57 ± 0.06***b 1.06 ± 0.06***b
TC (mg/dL) 109.83 ± 3.9 206.00 ± 4.53***a 179.50 ± 6.63**b 168.83 ± 6.16*** 147.66 ± 4.88***b
TG (mg/dL) 59.01 ± 2.74 151.16 ± 4.61***a 119.33 ± 3.8***b 96.81 ± 3.75***b 110.16 ± 5.26***b
HDL (mg/dL) 55.18 ± 2.40 25.25 ± 1.79*** 26.53 ± 1.22b 36.28 ± 1.78**b 40.41 ± 2.97**b
LDL (mg/dL) 42.84 ± 3.22 149.51 ± 4.28***a 130.10 ± 7.50*b 113.18 ± 7.60**b 85.21 ± 5.98***b
VLDL (mg/dL) 11.80 ± 0.54 30.23 ± 0.92***a 23.86 ± 0.76***b 19.36 ± 0.75***b 22.02 ± 1.05***b
TP (g/L) 113.76 ± 2.8 49.11 ± 1.82***a 53.88 ± 2.81b 71.452.64***b 91.81 ± 4.08***b
MDA (nmol/g) 0.50 ± 0.02 4.82 ± 0.29***a 4.47 ± 0.23b 2.75 ± 0.1***b 1.37 ± 0.16***b
NP-SH (nmol/g) 7.39 ± 0.53 3.86 ± 0.44***a 5.79 ± 0.35**b 5.93 ± 0.31**b 6.52 ± 0.31***b
  1. AST spartate aminotransaminase, ALT alanine aminotransaminase, ALP alkaline phosphatase, GGT γ-glutamyl transferase, BIL bilirubin, TC triglycerides, HDL high-density lipoproteins, LDL low-density lipoproteins, VLDL very low-density lipoproteins, TP total protein, MDA malondialdehyde, NP-SH nonprotein sulfhydryls. All values represent mean ± SEM. P < 0.05; P < 0.01; P < 0.001; ANOVA, followed by Dunnett’s multiple comparison test. aAs compared with control group (GI); bAs compared with CCl4-only group (GII)