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Table 1 Therapeutic effect of SSEE against CCl4-induced hepatotoxicity related parameters in rats

From: Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

Liver function parameters

GI (Control)

GII (CCl4-only)

GIII (CCl4+ SSEE 100 mg)

GIV (CCl4+ SSEE 200 mg)

GV (CCl4+ Silymarin 10 mg)

AST (U/L)

107.45 ± 5.31

294.83 ± 8.33***

288.50 ± 7.36 b

262.50 ± 6.87b

136.66 ± 6.00**b

ALT (U/L)

28.83 ± 2.20

230.83 ± 9.62***a

198.16 ± 7.12*b

159.50 ± 9.17***b

85.66 ± 4.31***b

ALP (U/L)

321.66 ± 13.8

515.16 ± 13.7***a

479.00 ± 6.12* b

436.33 ± 12.31**b

396.33 ± 7.62***b

GGT (U/L)

4.06 ± 0.32

12.85 ± 0.98***a

11.38 ± 0.49b

9.46 ± 0.32**b

5.58 ± 0.28***b

BIL (mg/dL)

0.54 ± 0.01

2.16 ± 0.08***a

1.81 ± 0.05*b

1.57 ± 0.06***b

1.06 ± 0.06***b

TC (mg/dL)

109.83 ± 3.9

206.00 ± 4.53***a

179.50 ± 6.63**b

168.83 ± 6.16***

147.66 ± 4.88***b

TG (mg/dL)

59.01 ± 2.74

151.16 ± 4.61***a

119.33 ± 3.8***b

96.81 ± 3.75***b

110.16 ± 5.26***b

HDL (mg/dL)

55.18 ± 2.40

25.25 ± 1.79***

26.53 ± 1.22b

36.28 ± 1.78**b

40.41 ± 2.97**b

LDL (mg/dL)

42.84 ± 3.22

149.51 ± 4.28***a

130.10 ± 7.50*b

113.18 ± 7.60**b

85.21 ± 5.98***b

VLDL (mg/dL)

11.80 ± 0.54

30.23 ± 0.92***a

23.86 ± 0.76***b

19.36 ± 0.75***b

22.02 ± 1.05***b

TP (g/L)

113.76 ± 2.8

49.11 ± 1.82***a

53.88 ± 2.81b

71.452.64***b

91.81 ± 4.08***b

MDA (nmol/g)

0.50 ± 0.02

4.82 ± 0.29***a

4.47 ± 0.23b

2.75 ± 0.1***b

1.37 ± 0.16***b

NP-SH (nmol/g)

7.39 ± 0.53

3.86 ± 0.44***a

5.79 ± 0.35**b

5.93 ± 0.31**b

6.52 ± 0.31***b

  1. AST spartate aminotransaminase, ALT alanine aminotransaminase, ALP alkaline phosphatase, GGT γ-glutamyl transferase, BIL bilirubin, TC triglycerides, HDL high-density lipoproteins, LDL low-density lipoproteins, VLDL very low-density lipoproteins, TP total protein, MDA malondialdehyde, NP-SH nonprotein sulfhydryls. All values represent mean ± SEM. P < 0.05; P < 0.01; P < 0.001; ANOVA, followed by Dunnett’s multiple comparison test. aAs compared with control group (GI); bAs compared with CCl4-only group (GII)