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Table 1 Summary of results

From: Modulation of neurological pathways by Salvia officinalis and its dependence on manufacturing process and plant parts used

receptor or Transporter IC50, μg dry mass/ml
Adrenergic alpha 2A 15 (8.7–24.5)
GABA (Bz-site) 89 (64–124)
GABAB 229 (119–440)
Muscarinic M3 25 (19–72)
μ-opioid 20 (12–35)
5-HTT 89 (28–283)
Serotonin 5-HT1A 19
(12–32)
Serotonin 5-HT2B 32
(14–71)
Serotonin 5-HT2C 60
(25–146)
Enzyme
Acetylcholinesterase > 400
  1. Data table to Fig. 1 supplemented by competition binding of Salvia officinalis extract at the GABAA (Bz-site) receptor, the GABAB receptor, the human serotonin 5-HT2B receptor expressed in CHO-K1 cells, and inhibition of acetylcholinesterase. Data are IC50 values and 95% confidence intervals of summary curves over 2–3 independent experiments performed in duplicate
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