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Table 1 Summary of results

From: Modulation of neurological pathways by Salvia officinalis and its dependence on manufacturing process and plant parts used

receptor or Transporter

IC50, μg dry mass/ml

Adrenergic alpha 2A

15 (8.7–24.5)

GABA (Bz-site)

89 (64–124)

GABAB

229 (119–440)

Muscarinic M3

25 (19–72)

μ-opioid

20 (12–35)

5-HTT

89 (28–283)

Serotonin 5-HT1A

19

(12–32)

Serotonin 5-HT2B

32

(14–71)

Serotonin 5-HT2C

60

(25–146)

Enzyme

Acetylcholinesterase

> 400

  1. Data table to Fig. 1 supplemented by competition binding of Salvia officinalis extract at the GABAA (Bz-site) receptor, the GABAB receptor, the human serotonin 5-HT2B receptor expressed in CHO-K1 cells, and inhibition of acetylcholinesterase. Data are IC50 values and 95% confidence intervals of summary curves over 2–3 independent experiments performed in duplicate