receptor or Transporter | IC50, μg dry mass/ml |
---|
Adrenergic alpha 2A | 15 (8.7–24.5) |
GABA (Bz-site) | 89 (64–124) |
GABAB | 229 (119–440) |
Muscarinic M3 | 25 (19–72) |
μ-opioid | 20 (12–35) |
5-HTT | 89 (28–283) |
Serotonin 5-HT1A | 19 (12–32) |
Serotonin 5-HT2B | 32 (14–71) |
Serotonin 5-HT2C | 60 (25–146) |
Enzyme |
Acetylcholinesterase | > 400 |
- Data table to Fig. 1 supplemented by competition binding of Salvia officinalis extract at the GABAA (Bz-site) receptor, the GABAB receptor, the human serotonin 5-HT2B receptor expressed in CHO-K1 cells, and inhibition of acetylcholinesterase. Data are IC50 values and 95% confidence intervals of summary curves over 2–3 independent experiments performed in duplicate