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Table 5 Summary of beneficial plant extract effectsa, b

From: Neutralization of cholera toxin by Rosaceae family plant extracts

extract Blocking of CTX binding to GM1 (ELISA)c;d Blocking of CTB binding to GM1 (ELISA)c;d Blocking of CTB binding
(cell assay)
Blocking of CTB internalization (cell assay)c Level of cAMP after CTX and plant extract treatinge Interaction with CTX by SDS-PAGEf Passg
agrimony 0.64 < 0.08 1.25 1.25 33 aggregation Yes
blackberry leaf 0.32 < 0.08 2.5 1.25 6.7 aggregation Yes
raspberry leaf 0.32 0.16 No 5.0 7.1 aggregation Yes
rosehip > 2.5g 1.25 No 10 35.8 dissociation Yes
wild strawberry leaf 0.64 0.32 2.5 1.25 9.7 aggregation Yes
  1. aEntries in bold indicate positive effects at, or below, traditional doses
  2. bAt least 50% Inhibition of harmful bacteria growth using traditional extract concentrations but no inhibition of beneficial L. rhamnosus
  3. cValues in mg/mL applied plant extract
  4. dInhibition at least 50% toxin bound to ganglioside GM1
  5. eValues in % compared to untreated cells (100%)
  6. fEffect seen at 1.3 or 2.6 mg/mL concentration of plant extract
  7. gMay attain 50% inhibition of toxin with traditional doses in the 4–10 mg/mL range