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Table 3 Effects of AqE on aorta remodeling in L-NAME induced hypertensive mice (mean ± SD, n = 10)

From: The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice

Group

TAA(×103μm2)

LA(×103μm2)

CSA(×103μm2)

CSA/TAA(%)

AR(μm)

Lumen(μm)

Media(μm)

M/L(%)

Control

424.5 ± 81.2

271.7 ± 66.6

152.8 ± 17.9

36.0 ± 22.0

366.4 ± 33.8

292.5 ± 33.9

73.9 ± 4.6

25.5 ± 3.0

Model

686.8 ± 162.3**

426.4 ± 97.1**

260.3 ± 73.1**

27.9 ± 45.0

464.8 ± 56.7**

366.3 ± 44.3**

98.5 ± 17.6**

27.0 ± 3.8

L-NAME+AqE

496.6 ± 81.5#

319.0 ± 59.6#

177.6 ± 22.0#

35.8 ± 27.0

396.5 ± 33.5#

317.5 ± 30.7

78.9 ± 2.9#

25.0 ± 1.7

L-NAME+XJEK

499.9 ± 65.2#

327.1 ± 59.5

172.9 ± 22.2#

34.6 ± 34.0

398.3 ± 26.7#

321.6 ± 29.4

76.6 ± 9.6#

24.1 ± 4.2

L-NAME+Fosinopril

445.1 ± 220.2#

292.5 ± 148.9#

153.2 ± 726.7#

34.4 ± 33.0

336.3 ± 159.0#

272.1 ± 129.2#

64.7 ± 30.0#

22.1 ± 6.5

  1. TAA total aorta area, LA lumen area, CSA cross-sectional area, AR aorta radius. The vascular remodeling of the upper thoracic aorta exposed to L-NAME was observed at the end of 8th week, which could be prevented by treatment with AqE for the last 4 weeks, as well as with two positive drugs, XJEK and fosinopril. Data are expressed as mean ± SD, n = 10. **P < 0.01 vs control; #P < 0.05 vs model