The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice

Table 3 Effects of AqE on aorta remodeling in L-NAME induced hypertensive mice (mean ± SD, n = 10)

Group	TAA(×10³μm²)	LA(×10³μm²)	CSA(×10³μm²)	CSA/TAA(%)	AR(μm)	Lumen(μm)	Media(μm)	M/L(%)
Control	424.5 ± 81.2	271.7 ± 66.6	152.8 ± 17.9	36.0 ± 22.0	366.4 ± 33.8	292.5 ± 33.9	73.9 ± 4.6	25.5 ± 3.0
Model	686.8 ± 162.3^**	426.4 ± 97.1^**	260.3 ± 73.1^**	27.9 ± 45.0	464.8 ± 56.7^**	366.3 ± 44.3^**	98.5 ± 17.6^**	27.0 ± 3.8
L-NAME+AqE	496.6 ± 81.5^#	319.0 ± 59.6^#	177.6 ± 22.0^#	35.8 ± 27.0	396.5 ± 33.5^#	317.5 ± 30.7	78.9 ± 2.9^#	25.0 ± 1.7
L-NAME+XJEK	499.9 ± 65.2^#	327.1 ± 59.5	172.9 ± 22.2^#	34.6 ± 34.0	398.3 ± 26.7^#	321.6 ± 29.4	76.6 ± 9.6^#	24.1 ± 4.2
L-NAME+Fosinopril	445.1 ± 220.2^#	292.5 ± 148.9^#	153.2 ± 726.7^#	34.4 ± 33.0	336.3 ± 159.0^#	272.1 ± 129.2^#	64.7 ± 30.0^#	22.1 ± 6.5

TAA total aorta area, LA lumen area, CSA cross-sectional area, AR aorta radius. The vascular remodeling of the upper thoracic aorta exposed to L-NAME was observed at the end of 8th week, which could be prevented by treatment with AqE for the last 4 weeks, as well as with two positive drugs, XJEK and fosinopril. Data are expressed as mean ± SD, n = 10. ^**P < 0.01 vs control; ^#P < 0.05 vs model

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