Fig. 4

Effects of polysaccharide extract from XJEK on HW/BW and cardiomyocyte CSA in L-NAME-induced hypertensive mice. (a) Representative image of a cardiomyocyte cross-section following HE staining (magnification, × 400). (b) Statistic alanalysis of cardiomyocyte CSA. (c) Representative image of a cardiomyocyte long axis following HE staining (magnification, × 400). (d) Statistical analysis of HW/BW. 1, Control group; 2,model group; 3,L-NAME+AqE group; 4,L-NAME+XJEK group; 5,L-NAME+fosinopril group. The HW/BW ratios and cardiomyocyte CSAs evidently increased in the model group compared with the control group. Subsequently, following 4 weeks of treatment with polysaccharide, the pathological changes were reversed, which could similarly be achieved with the positive control fosinopril. Data are presented as the mean ± SD (n = 10). ^*P < 0.05, ^**P < 0.01 vs. control group; ^##P < 0.01 vs. model group