Antibioticsa | Bacterial strainsb, MIC (μg/mL) of antibiotics in the absence and presence of compound 4 | ||||||||
---|---|---|---|---|---|---|---|---|---|
Compounds concentration | PA124 | KP55 | ATCC11296 | EA27 | ATCC13048 | AG102 | ATCC10536 | PBSS (%) | |
CIP | 0 | 2 | 0.5 | 0.5 | 0.5 | 4 | 2 | 0.125 | |
CMI/2 | 2 (1)I | 0.5(1)I | 0.25(0.5)S | 0.25(0.5)S | 0.5(0.125)S | 0.5(0.25)S | 0.125(1)I | (4/7) 57.14% | |
CMI/4 | 2 (1)I | 0.5(1)I | 0.25(0.5)S | 0.25(0.5)S | 0.5(0.125)S | 0.5(0.25)S | 0.125(1)I | (4/7) 57.14% | |
ERY | 0 | > 32 | 4 | > 32 | > 32 | > 32 | 16 | 16 | |
CMI/2 | 32 (0.5)S | 2(0.5)S | 4(< 0.125)S | 32 (0.5)S | 4(< 0.125)S | 4 (0.25)S | 8 (0.5)S | (7/7) 100% | |
CMI/4 | 32 (0.5)S | 2(0.5)S | 4(< 0.125)S | 32 (0.5)S | 8(< 0.25)S | 4 (0.25)S | 8 (0.5)S | (7/7) 100% | |
GEN | 0 | > 4 | 2 | > 4 | 4 | 4 | > 4 | 4 | |
CMI/2 | 4(0.5)S | 1(0.5)S | 0.0625(< 0.015)S | 1 (0.25)S | 2(0.5)S | 4(0.5)S | 0.5(0.125)S | (7/7) 100% | |
CMI/4 | 4(0.5)S | 2(1)I | 0.0625(< 0.015)S | 1 (0.25)S | (0.5)S | 4(0.5)S | 2(0.5)S | (6/7) 85.71% | |
KAN | 0 | 0.5 | 2 | 4 | 4 | 16 | 16 | 4 | |
CMI/2 | < 0.125(0.25)S | 1(0.5)S | 2(0.5)S | 4(1)I | 16(1)I | 16(1)I | 4(1)I | (3/7) 42.85% | |
CMI/4 | < 0.125(0.25)S | 2(1)I | 2(0.5)S | 4(1)I | 16(1)I | 16(1)I | 4(1)I | (2/7) 28.57% | |
NOR | 0 | > 16 | 16 | 1 | 16 | 16 | 2 | 1 | |
CMI/2 | 8(< 0.5)S | 2(0.125)S | 0.5(0.5)S | 4(0.25)S | 8(0.5)S | 2(1)I | 0.5(0.5)S | (6/7) 85.71% | |
CMI/4 | 8(< 0.5)S | 2(0.125)S | 0.5(0.5)S | 8(0.5)S | 8(0.5)S | 2(1)I | 0.5(0.5)S | (6/7) 85.71% | |
STR | 0 | > 32 | > 32 | > 32 | > 32 | > 32 | > 32 | > 32 | |
CMI/2 | 32(0.5)S | 32(0.5)S | 32(0.5)S | 16(< 0.5)S | 32(0.5)S | 16(< 0.5)S | 2(< 0.062)S | (7/7) 100% | |
CMI/4 | 32(0.5)S | 32(0.5)S | 32(0.5)S | 16(< 0.5)S | 32(0.5)S | 16(< 0.5)S | 2(< 0.062)S | (7/7) 100% | |
TET | 0 | 8 | 0.125 | > 16 | > 16 | > 16 | > 16 | 16 | |
CMI/2 | 4(0.5)S | 0.0625(0.5)S | 0.5(< 0.031)S | 4(< 0.25)S | 0.5(< 0.031)S | 2(< 0.125)S | 0.125(0.007)S | (7/7) 100% | |
CMI/4 | 4(0.5)S | 0.0625(0.5)S | 0.5(< 0.031)S | 8(< 0.5)S | 0.5(< 0.031)S | 2(< 0.125)S | 0.125(0.007)S | (7/7) 100% |