Fig. 3

The mRNA expressions levels of TNF-α, IL-6, IL-12p40 and IL-23 genes in hPBMCs obtained from psoriasis patients and healthy control treated with 20 μg/mL Na, 100 μg/mL Se and Na/Se combination (20/100 μg/mL at the ratio of 1:1 (v:v). The data showed the effect of naringin (Na) and sericin (Se) on hPBMCs-induced pro-inflammatory cytokine mRNA expression in hPBMCs (a). The patterns of induction fold of mRNA expression of all cytokines generally correlated with mRNA expression levels (b-e). *P < 0.001 vs. untreated control hPBMCs from healthy subjects by Mann-Whitney U test. #P < 0.05 and ## P < 0.001 vs. untreated pPBMCs from psoriasis patients by Mann-Whitney U test. ** P < 0.05 and *** P < 0.001 vs. treated hPBMC with Na/Se from psoriasis patients by Mann-Whitney U test