Fig. 3

STZ-NA-induced apoptosis and survival pathway signaling analysis in liver tissues. All protein samples from each rat group were analyzed by western blotting (n = 6). The cell survival proteins included p-PI3K, p-Akt and Bcl2, and apoptosis proteins included Cyto. c and Cle. Casp. 3 in the control rats, STZ-NA rats, and treatment group rats. The protein expression folds were normalized with tubulin. C: control; N: STZ-NA + HFD; L: Glossogyne tenuifolia low dose (50 mg/kg); H: Glossogyne tenuifolia high dose (150 mg/kg); P: acarbose (positive control). Data represent mean ± SEM. *p < 0.05, **p < 0.01 compared with the C group; #P < 0.05, ##P < 0.01 when compared with the N group