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Table 2 Minimal inhibitory concentration (MIC in mg/mL) and total activity (TA) in L of extract, fractions and isolated compounds of Oxyanthus speciosus. (TA in L is calculated by dividing mass of fraction in mg (MF) by MIC in mg/mL and dividing the answer by 1000)

From: Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity

Samples

Yield

(%)

MF

(mg)

Microorganisms

M. smegmatis

M. aurum

M. tuberculosis

M. fortuitum

Average

MIC

Average

TA inL

MIC

TA

MIC

TA

MIC

TA

MIC

TA

Extract

2.99a

26,340

0.08a

329.3

0.06a

439.0

0.17a

154.9

0.078

337.7

0.097

315.2

F1

2.02

750

1.25

0.6

2.5

0.3

2.5

0.3

2.5

0.3

2.19

0.3

F2

3.15

1160

0.31

3.7

0.625

1.8

0.625

1.9

0.31

3.7

1.02

2.8

F3

1.48

550

0.15

3.7

0.31

1.8

0.31

1.8

0.31

1.8

0.27

2.2

F4

3.08

1140

0.15

7.6

0.31

3.7

0.31

3.7

0.156

7.3

0.27

5.6

F5

1.64

610

0.15

4.1

0.31

1.9

2.5

0.2

0.625

0.9

0.78

1.8

F6

0.32

120

1.25

0.09

2.5

0.048

0.625

0.2

1.25

0.1

1.25

0.1

F7

0.43

160

1.25

0.1

0.625

0.3

1.25

0.1

1.25

0.1

1.09

0.2

F8

0.81

300

0.15

2

0.625

0.5

2.5

0.1

1.25

0.2

1.13

0.7

F9

0.08

30

0.039

0.8

0.31

0.09

0.31

0.09

0.625

0.05

0.48

0.3

F10

28.35

10,490

0.039

269

0.156

67.2

0.31

33.8

0.625

16.8

0.28

96.7

F11

29.81

11,030

0.15

73.5

0.156

71

0.31

35.6

0.625

17.6

0.31

33

Rif

nd

nd

12.5

nd

1.56

nd

100

nd

nd

nd

38.02

nd

Lut

nd

6.4

0.05

na

0.013

na

0.025

na

0.025

na

0.028

na

RA

nd

50

0.1

na

0.1

na

0.1

na

0.1

na

0.1

na

  1. Ms M. smegmatis, Ma M. aurum, Mt M. tuberculosis, Mf M. fortuitum, F1-F11 fractions, nd not determined, na not available, RA Rotundic acid, Rif Rifampicin, Lut Lutein
  2. aMICs previously published by Aro et al. [24]
  3. Values in bold indicates MIC and TA of fractions with good activites