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Table 3 IC50 DF of the characteristic compounds at concentrations levels present in HNE

From: Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment

Cell type

Macranthosid I (0.12 mg/ml)

Hellebosaponin A (1.31 mg/ml)

Hellebosaponin D (0.64 mg/ml)

Combined preparation

Caki-2

<  1:100

<  1:100

<  1:100

<  1:100

DLD-1

<  1:100

1:323

<  1:100

1:119

MKN-1

<  1:100

1:435

<  1:100

1:227

LN229

<  1:100

<  1:100

<  1:100

<  1:100

SK-N-SH

<  1:100

1:238

<  1:100

1:108

  1. Macranthosid I, hellebosaponin A and D are the characteristic compounds in HNE. These three compounds were isolated and investigated at concentration levels presented in HNE for their anti-proliferative potential by means of Alamar Blue assay. IC50 dilution factor (DF) of the combined preparation of all three compounds was examined in five tumor cell lines (Caki-2: renal cell carcinoma, DLD-1: colorectal carcinoma, MKN-1: gastric carcinoma, LN 229: glioblastoma, SK-N-SH: neuroblastoma) as well
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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