Fig. 1From: Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymesMechanism of the Nrf2 pathway. Under oxidative stress condition, Nrf2 separates from Keap1 via phosphorylation of it by various kinases. Nrf2 translocated into nucleus and binds to ARE region on promoter of the target gene including HO-1 and NQO-1Back to article page