Acute oral toxicity and antioxidant studies of an amine-based diselenide

Table 1 Effect of 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) on hepatic TBARS (Thiobarbituric acid reactive substances), NPSH (Non-protein thiol) and δ-ALA-D (Delta-aminolevulinic acid dehydratase) of mice

Groups(mg/kg)	TBARS^a	NPSH ^b	δ-ALA-D^c
Control	28.3 ± 1.2	8.3 ± 0.4	25.3 ± 3.4
APDP-10	30.2 ± 11.1	8.5 ± 2.0	23.5 ± 2.3
APDP-100	29.3 ± 2.1	8.2 ± 2.1	26.3 ± 1.5
APDP-350	33.1 ± 2.1	9.1 ± 2.9	25.2 ± 1.6

Data are reported as mean ± S.D. Data are reported as mean ± SD of seven animals per group. (*) Denoted p < 0.05 as compared to all groups (one-way ANOVA/Duncan). Data are expressed as ^anmol equivalents MDA (malondialdehyde) mg-1 protein, ^bμg ascorbic acid g-1 tissue, ^cU mg-1 protein and nmol of porphobilinogen mg-1 protein hour-1.

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