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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

Fig. 4

Effect of opioid receptor antagonists on PECN–induced antinociception assessed using the acetic acid–induced abdominal constriction test in mice. β–funaltrexamine (β–FNA; 10 mg/kg, i.p.), naltrindole (NALT; 1 mg/kg, i.p.), or nor–binaltorphimine (nor–BNI; 1 mg/kg, i.p.) were administered 90 min, 15 min and 30 min respectively, before oral administration of vehicle (10 mL/kg), or PECN (500 mg/kg). Each column represents the mean ± SEM of six mice. Statistical analyses were performed using one–way ANOVA followed by Dunnett’s post hoc test. ** p < 0.01, *** p < 0.01compared to control group. ### p < 0.001 compared to 500 mg/kg PECN–treated group

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