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Table 3 NK-cell activity and cytokine cluster analysis obtained prior to and after treatments from the two groups

From: Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

  Cordyceps mycelium extract group (n = 39) Placebo group (n = 40) p-valueb
Baseline Week 8 p-valuea Baseline Week 8 p-valuea  
NK-cell activity (%) 33.7 ± 17.4 38.8 ± 17.6 0.025* 37.9 ± 18.2 35.5 ± 19.9 0.282 0.019*
IL-1ß (pg/mL) 3.1 ± 1.3 3.1 ± 2.0 0.741 4.0 ± 7.7 2.7 ± 0.7 0.328 0.360
IL-2 (pg/mL) 3.0 ± 0.8 3.0 ± 0.7 0.446 2.9 ± 0.6 3.0 ± 0.5 0.166 0.126
IL-4 (pg/mL) 10.3 ± 2.7 10.2 ± 2.2 0.662 11.0 ± 6.8 10.9 ± 7.8 0.979 0.764
IL-10 (pg/mL) 5.1 ± 4.5 6.1 ± 6.3 0.205 3.8 ± 3.0 4.2 ± 3.0 0.277 0.458
IL-12 (pg/mL) 5.8 ± 6.2 6.0 ± 6.3 0.389 5.1 ± 3.3 5.2 ± 3.3 0.766 0.523
INF-γ (pg/mL) 10.4 ± 5.4 11.4 ± 7.1 0.100 10.0 ± 5.1 10.7 ± 6.7 0.275 0.741
TNF-α (pg/mL) 6.5 ± 1.5 6.8 ± 1.5 0.214 6.2 ± 1.5 6.6 ± 2.0 0.114 0.918
  1. Values are presented as the mean ± SD
  2. *p < 0.05
  3. aAnalyzed by a paired t-test within groups
  4. bAnalyzed by a linear mixed effect model for repeated measurement data between groups
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