Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

Table 3 NK-cell activity and cytokine cluster analysis obtained prior to and after treatments from the two groups

	Cordyceps mycelium extract group (n = 39)			Placebo group (n = 40)			p-value^b
	Baseline	Week 8	p-value^a	Baseline	Week 8	p-value^a
NK-cell activity (%)	33.7 ± 17.4	38.8 ± 17.6	0.025^*	37.9 ± 18.2	35.5 ± 19.9	0.282	0.019^*
IL-1ß (pg/mL)	3.1 ± 1.3	3.1 ± 2.0	0.741	4.0 ± 7.7	2.7 ± 0.7	0.328	0.360
IL-2 (pg/mL)	3.0 ± 0.8	3.0 ± 0.7	0.446	2.9 ± 0.6	3.0 ± 0.5	0.166	0.126
IL-4 (pg/mL)	10.3 ± 2.7	10.2 ± 2.2	0.662	11.0 ± 6.8	10.9 ± 7.8	0.979	0.764
IL-10 (pg/mL)	5.1 ± 4.5	6.1 ± 6.3	0.205	3.8 ± 3.0	4.2 ± 3.0	0.277	0.458
IL-12 (pg/mL)	5.8 ± 6.2	6.0 ± 6.3	0.389	5.1 ± 3.3	5.2 ± 3.3	0.766	0.523
INF-γ (pg/mL)	10.4 ± 5.4	11.4 ± 7.1	0.100	10.0 ± 5.1	10.7 ± 6.7	0.275	0.741
TNF-α (pg/mL)	6.5 ± 1.5	6.8 ± 1.5	0.214	6.2 ± 1.5	6.6 ± 2.0	0.114	0.918

Values are presented as the mean ± SD
^*p < 0.05
^aAnalyzed by a paired t-test within groups
^bAnalyzed by a linear mixed effect model for repeated measurement data between groups

ISSN: 2662-7671