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Table 2 α-glucosidase activity of methanolic extract of Cornus capitata and its fractions

From: In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants

Plant extract/Fractionate Percentage α-glucosidase inhibition IC 50 (μg/mL)
12.5 μg/mL 25 μg/mL 50 μg/mL 100 μg/mL 200 μg/mL 400 μg/mL  
Cornus capitata (Leaves) 63.68 ± 1.98a 97.81 ± 0.03a 98.37 ± 0.12a 97.43 ± 0.18a 97.18 ± 0.18 94.70 ± 0.41 12.5
Hexane Fraction 2.78 ± 2.73b 16.04 ± 4.78b 31.94 ± 5.17b 69.07 ± 2.51a 98.98 ± 1.22 96.52 ± 3.02 65.12
Diethyl ether Fraction 8.31 ± 0.87b 13.04 ± 2.80b 30.98 ± 4.21b 52.64 ± 6.11a 96.54 ± 0.92 95.65 ± 0.65 71.85
Ethyl acetate Fraction 14.60 ± 3.07bc 18.42 ± 2.65b 50.06 ± 0.36bc 84.45 ± 2.80a 98.55 ± 0.51 97.45 ± 1.08 50
n-Butanol Fraction 10.57 ± 0.21bc 14.93 ± 2.83b 26.07 ± 4.53bc 78.75 ± 4.63ab 98.35 ± 0.24 97.75 ± 0.43 61.175
  1. Values are mean ± S.E. of three parallel measurements
  2. Different letters indicate significant differences between same concentrations of Cornus capitata methanolic extract and its fractionates (p < 0.05, Tukeys HSD test, F-ratio- 49.935 (12.5 μg/mL), 55.279 (25 μg/mL), 46.702 (50 μg/mL), 16.690 (100 μg/mL), 1.861 (200 μg/mL), 0.683 (400 μg/mL)
  3. Cornus capitata methanolic extract (leaves) (4.25% at 1.5 μg/mL; 6% at 3.1 μg/mL and 19% inhibition at 6.25 μg/mL concentration)
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