Ocimum gratissimum Linn. Leaves reduce the key enzymes activities relevant to erectile dysfunction in isolated penile and testicular tissues of rats

Table 1 IC₅₀ values (μg/mL) of ferric reducing power, DPPH, PDE-5, arginase, ACE and AChE inhibitory activities in rat penile and testicular tissue by O. gratissimum leaf extracts and standard drugs/inhibitors

Sample	PDE-5 (μg/mL)	Arginase (μg/mL)	ACE (μg/mL)	AChE (μg/mL)	FRAP (μg/mL)	DPPH (μg/mL)
Penis	43.19 ± 0.02^c	46.12 ± 0.15^c	44.23 ± 0.71^a	55.51 ± 0.45^a	–	–
Testes	44.67 ± 0.01^b	49.12 ± 0.12^b	53.99 ± 0.85^a	60.03 ± 0.34^a	–	–
Sildenafil (μg/mL)	26.65 ± 0.10^a	–	–	–	–	–
L-NOHA (μg/mL)	–	42.48 ± 0.21^a	–	–	–	–
Lisinopril (μg/mL)	–	–	38.34 ± 0.01^a	–	–	–
Prostigmine (μg/mL)	–	–	–	48.01 ± 1.02^a	–	–
Vitamin C (μg/mL)	–	–	–	–	46.16 ± 0.51^a	53.81 ± 0.02^a
O. gratissimum extract	–	–	–	–	56.55 ± 0.78^a	69.41 ± 0.01^a

Values represent mean ± standard deviation (n = 3). Values with the same superscript along the column are not significant (p < 0.05) different. Sildenafil^*: standard drug for phosphodiesterase-5 (PDE-5); L-NOHA^*: standard inhibitor for arginase; prostigmine^*: standard drugs for AChE; Lisinopril^*: standard drug for ACE; Vitamin C^*: standard drug for ferric reducing power (FRAP) and DPPH

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