Fig. 4

Suppressive effects of Resv on HRPTEpiC-reactive proliferation of CD4⁺ PKH⁻T cells. We co-cultured PKH-67 labeled T cells with HRPTEpiCs and analyzed the differentiation of T cells by counting PKH (−) T cells. (a) The percentage of target cells was measured via flow cytometry. (b) The proportion (%) of proliferating CD4⁺ T cells. Bars show means. *P < 0.05 vs. Th17 polarizing condition ^†P < 0.05 vs. Tac 1 ng/mL group ^‡P < 0.05 vs. Tac 1 ng/mL group ^§P < 0.05 vs. Tac 1 ng/mL + Resv 25 μM group. Resv, Resveratrol; Tac, tacrolimus