Fig. 1

Results of three-point bending testing. a Tibias of AD control mice require less force and stress to fracture than wild type mice (*P < 0.05). Treatment with resveratrol and exercise increase ultimate force and ultimate stress (†P < 0.05), but not elastic modulus (P > 0.05) in comparison to AD controls. b Maximum bending moment was lowest in AD controls (*P < 0.05) and was reversed by resveratrol and exercise treatment (†P < 0.05). Tibias of AD control mice are less stiff than wild type mice *P < 0.05), but treatment did not affect tibial stiffness (†P > 0.05). Error bars are 2 ± SE