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Table 3 Overall summary in comparison with the UK Update report

From: Manual therapy for the pediatric population: a systematic review

Clinical condition UK update (1) summary Studies in current review Intervention Citations Quality Sample size Results of study Current study overall summary
Gastrointestinal Conditions
 Constipation Not evaluated 1 OBS OMT Tarsuslu, 2009 [18] Medium 13 No difference Inconclusive (unclear)
 Infantile Colic Inconclusive/ favorable 3 RCT
1 OBS
CMT Miller, 2012 [19]
Wiberg, 2010 [20]
Browning, 2008 [21]
Olafsdottir, 2001 [22]
High
Low
High
High
104
749
43
86
Improvement
No improvement
No difference
No difference
Inconclusive (unclear)
 Infantile Colic Inconclusive/ favorable 1 RCT OMT/CST Hayden, 2006 [23] Medium 28 Improvement Inconclusive (favorable)
 Pediatric dysfunctional voiding Inconclusive/ favorable 1 RCT OMT Nemett, 2008 [24] Medium 21 Improvement Inconclusive (favorable)
 Pediatric nocturnal enuresis Inconclusive/ favorable 1 OBS CMT van Poecke, 2009 [25] Medium 33 Improvement Inconclusive (unclear)
 Suboptimal infant breastfeeding Not evaluated 2 OBS CMT/CST Miller, 2009 [26]
Vallone, 2004 [27]
Medium
Low
114
25
Improvement Improvement Inconclusive (favorable)
Musculoskeletal Conditions
 Clubfoot Not evaluated 1 RCT MT Nilgun, 2011 [28] Low 29 Improvement Inconclusive (favorable)
 Cuboid Syndrome Not evaluated 1 OBS MT Jennings, 2005 [29] Medium 2 Improvement Inconclusive (unclear)
 Headache Not evaluated for pediatrics 1 OBS OMT Przekop, 2016 [30] Medium 83 Improvement Inconclusive (unclear)
 Headache Not evaluated for pediatrics 1 RCT MT Borusiak, 2010 [31] Medium 52 No difference Inconclusive (unclear)
 Headache Not evaluated for pediatrics 1 OBS CMT Marchand, 2009 [32] Low 13 Improvement Inconclusive (unclear)
 Low Back Pain Not evaluated 1 RCT
1 OBS
CMT Evans, 2018 [33]
Hayden J, 2003 [36]
High Medium 185
54
Improvement
Improvement
Moderate (favorable)
 Low back pain Not evaluated 1 OBS
1 RCT
MT Walston, 2016 [34]
Selhorst, 2015 [35]
Medium
Medium
3
35
Improvement
No difference
Inconclusive (unclear)
 Pulled (Nursemaid’s) Elbow Not evaluated 2 RCT MT Garcia-Mata, 2014 [37]
Bek, 2009 [38]
Medium
Medium
115
66
Improvement
Improvement
Moderate (favorable)
 Temporomandibular Joint Dysfunction Not evaluated for pediatrics 1 RCT OMT Monaco, 2008 [39] Low 28 Improvement Inconclusive (favorable)
Respiratory Conditions
 Asthma Not evaluated for pediatrics 1 RCT OMT Guiney, 2005 [40] Medium 140 Improvement Inconclusive (favorable)
 Asthma Not evaluated for pediatrics 1 RCT CMT Bronfort, 2001 [41] High 34 No improvement Inconclusive (unclear)
 Obstructive apnea Not evaluated 1 RCT OMT Vandenplas, 2008 [42] Medium 34 Improvement Inconclusive (favorable)
 Otitis Media Inconclusive/ unclear 3 RCT
1 OBS
OMT Steele, 2014 [43]
Wahl, 2008 [44]
Degenhardt, 2006 [45]
Mills, 2003 [47]
Medium
High
Medium
High
34
90
8
57
Improvement
No difference
Improvement
Improvement
Inconclusive (favorable)
 Otitis Media Not evaluated 1 OBS CMT Zhang, 2004 [46] Medium 22 Improvement Inconclusive (unclear)
Special Needs
 ADHD Inconclusive/ unclear 1 RCT OMT Accorsi, 2014 [48] High 28 Improvement Inconclusive (favorable)
 Autism Not evaluated 1 OBS VOMT Bramati-Castellarian, 2016 [49] Medium 49 Improvement Inconclusive (unclear)
Not evaluated 1 RCT CMT Khorshid, 2006 [50] Low 14 Improvement Inconclusive (favorable)
 Cerebral Palsy Inconclusive/ unclear 3 RCT OMT Wyatt, 2011 [51]
Duncan, 2008 [53]
Duncan, 2004 [52]
High
High
Low
142
55
50
No improvement
Improvement
Improvement
Inconclusive (unclear)
 Preterm infants Inconclusive/ unclear 4 RCT OMT/CST Raith, 2015 [54]
Cerretelli, 2015 [55]
Pizzolorusso, 2014 [56]
Cerretelli, 2013 [57]
High
High
High
High
30
695
110
110
No difference Improvement
Improvement
Improvement
Inconclusive/unclear for general movement Moderate (favorable) length of stay and hospital costs
Structural Conditions
 Cranial asymmetry Not evaluated 1 RCT MT/CST Cabrera-Martos, 2016 [58] High 46 Improvement Inconclusive (favorable)
Not evaluated 1 OBS OMT Lessard, 2011 [59] Medium 12 Improvement Inconclusive (unclear)
 Postural Asymmetry Not evaluated 1 RCT OMT/CST Phillippi, 2006 [60] High 32 Improvement Inconclusive (favorable)
 Scoliosis Not evaluated 1 RCT
3 OBS
CMT Byun, 2016 [61]
Rowe, 2006 [62]
Morningstar, 2004 [63]
Lantz, 2001 [64]
Medium
High
Low
Medium
5
6
6
42
Improvement
No difference
Improvement
No improvement
Inconclusive (unclear)
 Scoliosis Not evaluated 1 RCT OMT Hasler, 2010 [65] High 20 No improvement Inconclusive (unfavorable)
 Torticollis Not evaluated 1 RCT MT Haugen, 2011 [66] Medium 32 No difference Inconclusive (unfavorable)
 Upper cervical dysfunction Not evaluated 1 OBS MT Saedt, 2017 [67] High 307 Improvement Inconclusive (unclear)