Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study

Table 3 Hazard Ratios and 95% confidence intervals of fracture risk associated with cumulative use day of traditional Chinese herb medicine among osteoporosis patients

TCM used (days per year)	N	No. of Event	Hazard Ratio (95% CI)		Hazard Ratio (95% CI)
TCM used (days per year)	N	No. of Event	Crude	Adjusted^†	Crude	Adjusted^†
Non-TCM users or Chinese herb users < 30 days per year	1245	269	1(reference)	1(reference)	–	–
Chinese herb users (≥ 30 days per year) ^‡
30–180 days per year	270	43	0.63 (0.46–0.87)**	0.60 (0.43–0.84)**	1(reference)	1(reference)
180 days per year	93	11	0.42 (0.23–0.78)**	0.37 (0.20–0.68)**	0.65 (0.33–1.25)	0.63 (0.32–1.24)

Crude HR^* represented relative hazard ratio; Adjusted HR^† represented adjusted hazard ratio: mutually adjusted for age, gender, baseline comorbidity, and urbanization level in Cox proportional hazard regression
*p < 0.05, **p < 0.01, ***p < 0.001

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