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Table 7 Observations of micronucleus and PCE: RBC ratio – summary

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Dose (mg/kg/day) Animals per Dose MNPCE/2000 PCE PCE:RBC Ratio (% Control)
0 4 1.00 ± 0.82 0.52 ± 0.05 100
500 4 2.25 ± 1.26 0.58 ± 0.07 110
1000 4 1.50 ± 1.29 0.62 ± 0.04 119
2000 4 1.50 ± 1.00 0.55 ± 0.08 104
5000 4 1.00 ± 0.82 0.56 ± 0.08 106
CPA 70 4 78.25 ± 4.86* 0.52 ± 0.06 99
  1. OE: Opuntia ficus-indica var. saboten extract, MNPCE: Micronucleated polychromatic erythrocyte, PCE: Polychromatic erythrocyte, RBC: Red blood cells (polychromatic erythrocyte+normochromatic erythrocyte), CPA: Cyclophosphamide monohydrate (positive control article)
  2. The data are reported as the mean ± SD. The non-parametric Kruskal-Wallis test was performed on the frequency of micronucleus using SPSS Statistics 22 for Medical Science in the micronucleus test, and the negative and positive controls data were analyzed using the Mann-Whitney U test. *Significantly different from the negative control group at P < 0.05