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Table 3 Effect of oral administration of OE on hematological parameters

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Tests Male Female
G1 G2 G3 G4 G1 G2 G3 G4
RBC (106/μL) 6.91 ± 0.43 7.23 ± 0.27 6.85 ± 0.38 6.81 ± 0.17 7.05 ± 0.16 7.25 ± 0.25 7.05 ± 0.08 6.89 ± 0.31
HGB (g/dL) 13.5 ± 0.6 14.2 ± 0.2 13.6 ± 0.7 13.7 ± 0.3 13.9 ± 0.2 14.1 ± 0.3 13.8 ± 0.1 13.6 ± 0.7
HCT (%) 40.8 ± 2.0 42.7 ± 0.8 41.3 ± 1.9 40.5 ± 0.6 40.7 ± 0.3 41.7 ± 0.7 40.6 ± 0.3 40.1 ± 1.6
MCV (fL) 59.1 ± 0.9 59.1 ± 1.1 60.3 ± 0.8 59.5 ± 0.6 57.8 ± 1.0 57.6 ± 1.0 57.5 ± 0.8 58.2 ± 0.5
MCH (pg) 19.5 ± 0.3 19.6 ± 0.5 19.8 ± 0.5 20.1 ± 0.5 19.8 ± 0.4 19.4 ± 0.4 19.6 ± 0.3 19.7 ± 0.2
MCHC (g/dL) 32.9 ± 0.2 33.2 ± 0.2 32.9 ± 1.0 33.8 ± 0.8 34.3 ± 0.5 33.7 ± 0.4 34.0 ± 0.2 33.9 ± 0.7
RDW (%) 12.6 ± 0.8 11.8 ± 0.1 12.9 ± 0.7 12.3 ± 0.3 11.4 ± 0.3 11.4 ± 0.3 11.4 ± 0.4 12.2 ± 0.3*
HDW (g/dL) 2.32 ± 0.07 2.21 ± 0.05 2.22 ± 0.04 2.22 ± 0.07 2.16 ± 0.08 2.17 ± 0.10 2.09 ± 0.06 2.24 ± 0.05
PLT (103/μL) 1404.7 ± 280.7 1196.7 ± 292.9 1274.3 ± 31.8 1149.7 ± 133.6 1078.0 ± 128.6 1091.7 ± 72.0 1132.3 ± 80.1 1204.7 ± 88.4
MPV (fL) 5.50 ± 0.17 5.57 ± 0.23 5.53 ± 0.23 5.60 ± 0.17 5.40 ± 0.17 5.67 ± 0.21 5.40 ± 0.26 5.37 ± 0.06
WBC (103/μL) 5.56 ± 2.15 6.23 ± 1.90 7.40 ± 3.07 5.63 ± 1.12 4.33 ± 1.75 4.89 ± 1.32 3.75 ± 0.78 4.86 ± 1.65
NEU (103/μL) 0.4 ± 0.1 0.5 ± 0.1 0.5 ± 0.2 0.4 ± 0.2 0.3 ± 0.1 0.5 ± 0.3 0.3 ± 0.1 0.4 ± 0.2
LYM (103/μL) 5.0 ± 1.9 5.5 ± 1.7 6.6 ± 2.7 5.0 ± 0.9 3.8 ± 1.6 4.1 ± 1.3 3.3 ± 0.7 4.3 ± 1.3
MON (103/μL) 0.15 ± 0.09 0.14 ± 0.05 0.19 ± 0.10 0.16 ± 0.04 0.10 ± 0.05 0.10 ± 0.06 0.08 ± 0.04 0.09 ± 0.03
EOS (103/μL) 0.03 ± 0.01 0.04 ± 0.02 0.04 ± 0.01 0.03 ± 0.01 0.06 ± 0.02 0.08 ± 0.05 0.05 ± 0.01 0.08 ± 0.04
BAS (103/μL) 0.01 ± 0.01 0.01 ± 0.01 0.02 ± 0.01 0.01 ± 0.01 0.00 ± 0.01 0.00 ± 0.00 0.01 ± 0.01 0.01 ± 0.01
LUC (103/μL) 0.04 ± 0.02 0.03 ± 0.01 0.06 ± 0.04 0.03 ± 0.01 0.02 ± 0.02 0.03 ± 0.01 0.03 ± 0.02 0.03 ± 0.01
  1. G1: negative control vehicle treated group; G2: 500 mg/kg OE treated group; G3: 1000 mg/kg OE treated group; G4: 2000 mg/kg OE treated group
  2. RBC: erythrocyte; HGB: hemoglobin: HCT: hematocrit; MCV: mean corpuscular volume: MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: Red cell distribution width; HDW: Hemoglobin distribution width; PT: Platelet; MPV: Mean platelet volume; WBC: white blood cell; NEU: Neutrophil; LYM: Lymphocyte; MON: Monocyte; EOS: Eosinophil; BAS: Basophils; LUC: Large unstained cell. Data are expressed as mean ± SD. *Significant difference at P < 0.05 levels compared with the G1 group. Bonferroni’s post hoc test was used following a one-way ANOVA vs. G1, and the homogeneity of variance was tested using Levene’s test