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Table 1 Effect of oral administration of OE on body weight, food and water consumption, and relative organs weight to body weight

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

  Male Female
G1 G2 G3 G4 G1 G2 G3 G4
IBW (g) 200.81 ± 12.55 198.09 ± 7.90 201.98 ± 8.35 202.77 ± 12.53 144.92 ± 5.29 149.25 ± 6.00 153.67 ± 9.68 160.69 ± 6.01
FBW (g) 220.79 ± 15.32 211.72 ± 7.37 219.15 ± 10.37 217.26 ± 9.93 161.83 ± 2.88 166.26 ± 7.00 173.32 ± 12.22 173.29 ± 3.79
Food consumption g/day 20.91 ± 1.11 19.46 ± 1.20 20.14 ± 0.91 20.11 ± 0.79 12.95 ± 1.32 14.61 ± 1.01 15.39 ± 0.31 15.10 ± 0.05
Water consumption mL/day 22.83 ± 1.13 24.14 ± 0.82 24.42 ± 0.35 25.27 ± 0.08 22.10 ± 0.93 17.26 ± 1.42 20.95 ± 0.35 22.03 ± 0.73
Adrenal gland-left 0.0193 ± 0.003 0.0174 ± 0.001 0.0214 ± 0.002 0.0195 ± 0.004 0.0212 ± 0.003 0.0224 ± 0.002 0.0247 ± 0.004 0.0217 ± 0.002
% to BW 0.009 ± 0.001 0.008 ± 0.001 0.010 ± 0.001 0.009 ± 0.002 0.015 ± 0.001 0.015 ± 0.001 0.016 ± 0.002 0.014 ± 0.001
Adrenal gland-right 0.017 ± 0.002 0.018 ± 0.001 0.021 ± 0.003 0.019 ± 0.003 0.021 ± 0.004 0.021 ± 0.002 0.024 ± 0.005 0.022 ± 0.002
% to BW 0.008 ± 0.001 0.008 ± 0.000 0.009 ± 0.001 0.009 ± 0.002 0.015 ± 0.002 0.014 ± 0.001 0.015 ± 0.003 0.014 ± 0.001
Thymus 0.631 ± 0.076 0.572 ± 0.168 0.694 ± 0.105 0.614 ± 0.057 0.368 ± 0.046 0.438 ± 0.043 0.385 ± 0.041 0.441 ± 0.052
% to BW 0.285 ± 0.016 0.271 ± 0.080 0.316 ± 0.040 0.283 ± 0.023 0.255 ± 0.042 0.293 ± 0.019 0.250 ± 0.015 0.276 ± 0.043
Spleen 0.697 ± 0.058 0.574 ± 0.091 0.653 ± 0.045 0.616 ± 0.028 0.434 ± 0.078 0.411 ± 0.023 0.423 ± 0.072 0.467 ± 0.032
% to BW 0.316 ± 0.007 0.272 ± 0.050 0.298 ± 0.008 0.284 ± 0.024 0.299 ± 0.046 0.276 ± 0.021 0.275 ± 0.041 0.290 ± 0.009
Kidney-left 0.877 ± 0.079 0.797 ± 0.044 0.851 ± 0.034 0.895 ± 0.011 0.624 ± 0.085 0.596 ± 0.025 0.619 ± 0.058 0.653 ± 0.083
% to BW 0.397 ± 0.008 0.377 ± 0.031 0.388 ± 0.007 0.412 ± 0.014 0.430 ± 0.051 0.399 ± 0.017 0.403 ± 0.026 0.406 ± 0.043
Kidney-right 0.889 ± 0.056 0.818 ± 0.064 0.876 ± 0.012 0.897 ± 0.010 0.637 ± 0.069 0.588 ± 0.008 0.608 ± 0.062 0.667 ± 0.057
% to BW 0.403 ± 0.010 0.387 ± 0.037 0.400 ± 0.017 0.414 ± 0.022 0.440 ± 0.044 0.395 ± 0.021 0.396 ± 0.029 0.415 ± 0.026
Heart 0.945 ± 0.161 0.782 ± 0.042 0.868 ± 0.047 0.905 ± 0.069 0.620 ± 0.015 0.620 ± 0.024 0.626 ± 0.066 0.620 ± 0.068
% to BW 0.426 ± 0.046 0.370 ± 0.033 0.396 ± 0.008 0.416 ± 0.020 0.428 ± 0.023 0.415 ± 0.002 0.409 ± 0.048 0.386 ± 0.038
Lung 1.243 ± 0.111 1.048 ± 0.081 1.138 ± 0.079 1.159 ± 0.082 0.912 ± 0.042 0.882 ± 0.104 0.950 ± 0.105 1.031 ± 0.110
% to BW 0.562 ± 0.012 0.495 ± 0.043 0.519 ± 0.034 0.534 ± 0.043 0.629 ± 0.018 0.590 ± 0.052 0.620 ± 0.076 0.641 ± 0.058
Brain 1.918 ± 0.027 1.825 ± 0.049 1.858 ± 0.108 1.904 ± 0.027 1.741 ± 0.044 1.825 ± 0.084 1.788 ± 0.065 1.750 ± 0.113
% to BW 0.871 ± 0.049 0.863 ± 0.047 0.849 ± 0.047 0.877 ± 0.029 1.202 ± 0.043 1.223 ± 0.008 1.168 ± 0.111 1.090 ± 0.083
Liver 7.564 ± 1.085 6.768 ± 0.356 7.725 ± 0.576 7.464 ± 0.520 4.915 ± 0.143 4.815 ± 0.518 4.830 ± 0.213 5.158 ± 0.200
% to BW 3.417 ± 0.259 3.196 ± 0.097 3.531 ± 0.334 3.439 ± 0.257 3.393 ± 0.073 3.223 ± 0.253 3.147 ± 0.119 3.211 ± 0.082
  1. G1: negative control; G2: 500 mg/kg OE treated group; G3: 1000 mg/kg OE treated group; G4: 2000 mg/kg OE treated group. IBW: initial body weight; FBW: final body weight
  2. Data are expressed as mean ± SD. Bonferroni’s post hoc test was used following a one-way ANOVA vs. G1, and the homogeneity of variance was tested using Levene’s test. There was no significance difference among all the groups