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Table 2 Effects of compounds 1–8 on IL-6/STAT3 activity in HepG2/STAT3 cells

From: 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

compound

1

2

3

4

5

6

7

8

pyridone 6

IC50

(μM)

7.75 ± 0.18

40.20 ± 0.17

> 100

> 100

> 100

> 100

> 100

> 100

0.02 ± 0.001