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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Fig. 5

MCF-7 cell cycle analysis of cells treated with (a) VAEM (b) endoxifen and (c) 1 μM endoxifen and VAEM, both in presence or absence of β-estradiol (E2), respectively. Cells were harvested after 3d, fixed, stained and analyzed for DNA content by flow cytometry. The distribution and percentage of cells in G0/G1, S and G2/M phase of the cell cycle are indicated. Results are presented as mean values from six independent experiments. (SE values are omitted for clarity). Significance values are given relative to the VAEM and endoxifen untreated controls (*p < 0.05, **p < 0.01, ***p < 0.001). Discrepancies from 100% can be attributed to slight gating differences and the display of mean values

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