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Table 2 Prothrombin time (PT) and International Normalized Ratio (INR) measurements of different rat groups treated with the natural products and their quality markers alone or in combination with warfarin

From: Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts

Treatment Test
  PT (s) INR
Negative control 17.3 ± 0.53 1.0 ± 0.04
WF 191 ± 12 19 ± 1**
PPE 21.5 ± 1.2# 1.3 ± 0.09#
WF + PPE 360 ± 36.9** 42 ± 5.3**
EA 23 ± 1.31# 1.43 ± 0.10#
WF + EA 414 ± 139** 51 ± 19**
GvL 23.3 ± 1.04# 1.44 ± 0.08#
WF + GvL 425 ± 57** 52 ± 8.4**
QUE 22.5 ± 1.20# 1.39 ± 0.09#
WF + QUE 448 ± 79** 55 ± 11**
  1. Each data point represents the mean ± SD (n = 8). **p < 0.01 (in comparison with warfarin alone). # p < 0.01 (in comparison with the negative control)