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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts

Fig. 5

Percentage of CYP3A4 activity relative to untreated isolated hepatocytes of different groups treated with ketoconazole (1 μg/ml) and warfarin (3 μg/ml) alone or in combination with: (a) pomegranate peel extract (120 μg/ml), ellagic acid (48 μg/ml) or, (b) guava leaves extract (294.1 μg/ml) and quercetin (15 μg/ml). Each data point represents the mean ± SD (n = 6). Statistical evaluation was performed by comparing the percentage of activity of untreated cells with treated cells *p < 0.05, **p < 0.01

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